Pharmacokinetics, Safety, and Tolerability of Cefiderocol, a Novel Siderophore Cephalosporin for Gram-Negative Bacteria, in Healthy Subjects

• Published in: Antimicrobial agents and chemotherapy Vol. 62; no. 3
• Main Authors: Saisho, Yutaka, Katsube, Takayuki, White, Scott, Fukase, Hiroyuki, Shimada, Jingoro
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.03.2018
• Subjects: Adult; Anti-Bacterial Agents; Anti-Bacterial Agents - blood; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - urine; Area Under Curve; Cefiderocol; Cephalosporins; Cephalosporins - blood; Cephalosporins - pharmacokinetics; Cephalosporins - urine; Drug Administration Schedule; Drug Dosage Calculations; Female; Half-Life; Healthy Volunteers; Humans; Japan; Male; Middle Aged; Pharmacology; Siderophores; Siderophores - blood; Siderophores - pharmacokinetics; Siderophores - urine; Japan; cefiderocol; pharmacokinetics; Gram-negative bacteria; cephalosporin; siderophores

Cefiderocol is a novel parenteral siderophore cephalosporin that shows potent efficacy against various Gram-negative bacteria, including carbapenem-resistant strains, in vitro and in preclinical models of infection. The aim of the present study was to evaluate the pharmacokinetics (PK), safety, and...