Identification of Two Critical Neutralizing Epitopes in the Receptor Binding Domain of Hepatitis B Virus preS1

• Published in: Journal of virology Vol. 95; no. 5
• Main Authors: Yato, Keigo, Onodera, Taishi, Matsuda, Mami, Moriyama, Saya, Fujimoto, Akira, Watashi, Koichi, Aizaki, Hideki, Tanaka, Tomohisa, Moriishi, Kohji, Nishitsuji, Hironori, Shimotohno, Kunitada, Tamura, Koji, Takahashi, Yoshimasa, Wakita, Takaji, Muramatsu, Masamichi, Kato, Takanobu, Suzuki, Ryosuke
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.03.2021
• Subjects: Vaccines and Antiviral Agents; neutralizing antibodies; epitope; HBV; preS1

The HBV preS1 amino acid 2 to 47 region (preS1/2–47) is essential for virus binding to sodium taurocholate cotransporting polypeptide. Several MAbs targeting preS1/2–47 have been reported to neutralize HBV infection; however, which region in preS1/2–47 contains the critical neutralizing epitope(s) f...