Idea2Data: Toward a New Paradigm for Drug Discovery

• Published in: ACS medicinal chemistry letters Vol. 10; no. 3; pp. 278 - 286
• Main Authors: Nicolaou, Christos A, Humblet, Christine, Hu, Hong, Martin, Eva M, Dorsey, Frank C, Castle, Thomas M, Burton, Keith Ian, Hu, Haitao, Hendle, Jorg, Hickey, Michael J, Duerksen, Joel, Wang, Jibo, Erickson, Jon A
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 14.03.2019; American Chemical Society (ACS)
• Subjects: 60 APPLIED LIFE SCIENCES; automated synthesis; Hit identification; Innovations; INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; ULK1 serine/threonine protein kinase; virtual screening; automated synthesis; ULK1 serine/threonine protein kinase; virtual screening; Hit identification

Increasing the success rate and throughput of drug discovery will require efficiency improvements throughout the process that is currently used in the pharmaceutical community, including the crucial step of identifying hit compounds to act as drivers for subsequent optimization. Hit identification c...