The Epstein-Barr Virus Enhancer Interaction Landscapes in Virus-Associated Cancer Cell Lines

• Published in: Journal of virology Vol. 96; no. 18; p. e0073922
• Main Authors: Ding, Weiyue, Wang, Chong, Narita, Yohei, Wang, Hongbo, Leong, Merrin Man Long, Huang, Alvin, Liao, Yifei, Liu, Xuefeng, Okuno, Yusuke, Kimura, Hiroshi, Gewurz, Benjamin, Teng, Mingxian, Jin, Shuilin, Sato, Yoshitaka, Zhao, Bo
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 28.09.2022
• Subjects: Cell Line, Tumor; Enhancer Elements, Genetic - genetics; Epstein-Barr Virus Infections - genetics; Epstein-Barr Virus Infections - virology; Epstein-Barr Virus Nuclear Antigens - genetics; Genome and Regulation of Viral Gene Expression; Genome Replication and Regulation of Viral Gene Expression; Herpesvirus 4, Human - genetics; Humans; MicroRNAs - metabolism; Neoplasms - virology; Plasmids - chemistry; Plasmids - genetics; Plasmids - metabolism; Viral Proteins - genetics; Virology; Virus Latency - genetics; Epstein-Barr virus; episome; 3D genome organization; latency

EBV is the first human DNA tumor virus identified, discovered over 50 years ago. EBV causes ~200,000 cases of various cancers each year. Epstein-Barr virus (EBV) persists in human cells as episomes. EBV episomes are chromatinized and their 3D conformation varies greatly in cells expressing different...