Dose Selection for an Adjuvanted Respiratory Syncytial Virus F Protein Vaccine for Older Adults Based on Humoral and Cellular Immune Responses - Falloon, Judith; Talbot, H. Keipp; Curtis, Craig; Ervin, John; Krieger, Diane; Dubovsky, Filip; Takas, Therese; Yu, Jing; Yu, Li; Lambert, Stacie L.; Villafana, Tonya; Esser, Mark T. (Clinical and vaccine immunology, 2017)
Keywords: Adjuvants, Immunologic; Adult; Aged; Aged, 80 and over; Antibodies, Neutralizing - blood; Antibodies, Viral - blood; Dose-Response Relationship, Immunologic; Double-Blind Method; Enzyme-Linked Immunospot Assay; Female; Glucosides; Glucosides - immunology; Humans; Immunity, Cellular; Immunity, Humoral; Immunogenicity, Vaccine; Immunoglobulin G - blood; Influenza Vaccines - administration & dosage; Influenza Vaccines - immunology; Influenza, Human - immunology; Interferon-gamma - biosynthesis; Interferon-gamma - immunology; Lipid A; Lipid A - immunology; Male; Middle Aged; Respiratory Syncytial Virus Infections - immunology; Respiratory Syncytial Virus Infections - prevention & control; Respiratory Syncytial Virus Vaccines; Respiratory Syncytial Virus Vaccines - administration & dosage; Respiratory Syncytial Virus Vaccines - chemistry; Respiratory Syncytial Virus Vaccines - genetics; Respiratory Syncytial Virus Vaccines - immunology; Respiratory Syncytial Virus, Human; Respiratory Syncytial Virus, Human - immunology; T-Lymphocytes - immunology; Vaccines; Viral Fusion Proteins; Viral Fusion Proteins - administration & dosage; Viral Fusion Proteins - genetics; Viral Fusion Proteins - immunology; vaccine; adult; adjuvant; respiratory syncytial virus; TLR-4 agonist; cell-mediated immunity