Dissecting Naturally Arising Amino Acid Substitutions at Position L452 of SARS-CoV-2 Spike

• Published in: Journal of virology Vol. 96; no. 20; p. e0116222
• Main Authors: Tan, Toong Seng, Toyoda, Mako, Ode, Hirotaka, Barabona, Godfrey, Hamana, Hiroshi, Kitamatsu, Mizuki, Kishi, Hiroyuki, Motozono, Chihiro, Iwatani, Yasumasa, Ueno, Takamasa
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 26.10.2022
• Subjects: Amino Acid Substitution; Amino Acids - genetics; COVID-19; Genetic Diversity and Evolution; Humans; Immune Sera; Mutation; Nucleotides; SARS-CoV-2 - genetics; Spike Glycoprotein, Coronavirus - metabolism; Virology; mutational studies; SARS-CoV-2; substitution; L452; fitness; spike protein; coronavirus; spike

In a span of less than 3 years since the declaration of the coronavirus pandemic, numerous SARS-CoV-2 variants of concern have emerged all around the globe, fueling a surge in the number of cases and deaths that caused severe strain on the health care system. A major concern is whether viral evoluti...