Self-Assembly of Catenanes from Lasso Peptides

• Published in: Journal of the American Chemical Society Vol. 138; no. 43; pp. 14214 - 14217
• Main Authors: Allen, Caitlin D, Link, A. James
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 02.11.2016
• Subjects: Animals; Catenanes - chemistry; Models, Molecular; Peptides - chemistry; Protein Conformation; Temperature

Lasso peptides exist naturally in a threaded state as [1]­rotaxanes, and we reasoned that lasso peptides cleaved in their loop region could serve as building blocks for catenanes. Mutagenesis of the lasso peptide microcin J25 (MccJ25) with two cysteine residues followed by cleavage of the peptide wi...