In Vivo Photocontrol of Microtubule Dynamics and Integrity, Migration and Mitosis, by the Potent GFP-Imaging-Compatible Photoswitchable Reagents SBTubA4P and SBTub2M

• Published in: Journal of the American Chemical Society Vol. 144; no. 12; pp. 5614 - 5628
• Main Authors: Gao, Li, Meiring, Joyce C. M, Varady, Adam, Ruider, Iris E, Heise, Constanze, Wranik, Maximilian, Velasco, Cecilia D, Taylor, Jennifer A, Terni, Beatrice, Weinert, Tobias, Standfuss, Jörg, Cabernard, Clemens C, Llobet, Artur, Steinmetz, Michel O, Bausch, Andreas R, Distel, Martin, Thorn-Seshold, Julia, Akhmanova, Anna, Thorn-Seshold, Oliver
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 30.03.2022
• Subjects: Animals; Cytoskeleton; Indicators and Reagents - metabolism; Microtubules - metabolism; Mitosis; Zebrafish

Photoswitchable reagents are powerful tools for high-precision studies in cell biology. When these reagents are globally administered yet locally photoactivated in two-dimensional (2D) cell cultures, they can exert micron- and millisecond-scale biological control. This gives them great potential for...