Spliceostatins and Derivatives: Chemical Syntheses and Biological Properties of Potent Splicing Inhibitors

• Published in: Journal of natural products (Washington, D.C.) Vol. 84; no. 5; pp. 1681 - 1706
• Main Authors: Ghosh, Arun K, Mishevich, Jennifer L, Jurica, Melissa S
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society and American Society of Pharmacognosy 28.05.2021
• Subjects: Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - pharmacology; Biological Products - chemical synthesis; Biological Products - pharmacology; cytotoxicity; Humans; moieties; Molecular Structure; neoplasm cells; Pyrans - chemical synthesis; Pyrans - pharmacology; RNA Splicing - drug effects; spliceosomes; Spliceosomes - drug effects

Spliceostatins and thailanstatins are intriguing natural products due to their structural features as well as their biological significance. This family of natural products has been the subject of immense synthetic interest because they exhibit very potent cytotoxicity in representative human cancer...