Identification and characterization of deoxyguanosine adducts of methyl vinyl ketone and ethyl vinyl ketone. Genotoxicity of the ketones in the SOS chromotest

• Published in: Chemical research in toxicology Vol. 4; no. 1; pp. 50 - 57
• Main Authors: Eder, Erwin, Hoffman, Christian, Deininger, Christoph
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.01.1991
• Subjects: Biological and medical sciences; Butanones - metabolism; Butanones - toxicity; Chemical mutagenesis; Chromatography; Deoxyguanosine - metabolism; Guanine - metabolism; Medical sciences; Nucleosides - metabolism; Pentanones - metabolism; Pentanones - toxicity; SOS Response (Genetics) - drug effects; Toxicology; SOS chromotest; Mutagenicity testing; Toxicity; Enone; Molecular adduct

The reaction of the alpha, beta-unsaturated ketones methyl vinyl ketone (MVK) and ethyl vinyl ketone (EVK) with nucleosides and 5'-mononucleotides was studied. The genotoxic activity of MVK and EVK in the SOS Chromotest was investigated. Three different types of adducts with deoxyguanosine were...