Posaconazole Tablet Pharmacokinetics: Lack of Effect of Concomitant Medications Altering Gastric pH and Gastric Motility in Healthy Subjects

• Published in: Antimicrobial agents and chemotherapy Vol. 58; no. 7; pp. 4020 - 4025
• Main Authors: Kraft, Walter K., Chang, Peter S., van Iersel, Marlou L. P. S., Waskin, Hetty, Krishna, Gopal, Kersemaekers, Wendy M.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.07.2014
• Subjects: Adult; Antacids - pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal Agents; Antifungal Agents - administration & dosage; Antifungal Agents - adverse effects; Antifungal Agents - pharmacokinetics; Area Under Curve; Biological and medical sciences; Clinical Therapeutics; Drug Interactions; Female; Gastric Acid; Gastric Acid - physiology; Gastrointestinal Motility; Gastrointestinal Motility - physiology; Healthy Volunteers; Histamine H1 Antagonists - pharmacology; Humans; Hydrogen-Ion Concentration; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Proton Pump Inhibitors - pharmacology; Tablets; Triazoles; Triazoles - administration & dosage; Triazoles - adverse effects; Triazoles - pharmacokinetics; Young Adult; Human; Drug; Stomach; Motility; Healthy subject; Digestive system; Azole derivatives; Antifungal agent; Triazole derivatives; Dosage form; pH; Tablet; Pharmacokinetics; Posaconazole

Posaconazole oral suspension is an extended-spectrum triazole that should be taken with food to maximize absorption. A new posaconazole tablet formulation has demonstrated improved bioavailability over the oral suspension in healthy adults in a fasting state. This study evaluated the effects of conc...