Discrimination of SARS-CoV-2 Omicron Sublineages BA.1 and BA.2 Using a High-Resolution Melting-Based Assay: a Pilot Study

• Published in: Microbiology spectrum Vol. 10; no. 4; p. e0136722
• Main Authors: Aoki, Akira, Adachi, Hirokazu, Mori, Yoko, Ito, Miyabi, Sato, Katsuhiko, Okuda, Kenji, Sakakibara, Toru, Okamoto, Yoshinori, Jinno, Hideto
• Format: Journal Article
• Language: English
• Published: 1752 N St., N.W., Washington, DC American Society for Microbiology 31.08.2022
• Subjects: BA.1; BA.2; Clinical Microbiology; high-resolution melting; Omicron variant; receptor-binding domain; Research Article; SARS-CoV-2; Omicron variant; SARS-CoV-2; BA.1; BA.2; high-resolution melting; receptor-binding domain

This study seeks to apply a novel high-resolution melting (HRM) assay to identify and discriminate BA.1 and BA.2 sublineages of the SARS-CoV-2 Omicron variant. Variant BA.2 may cause more severe disease than variant BA.1, meaning that identifying this variant is an important step toward improving th...