The Population Genomics of Increased Virulence and Antibiotic Resistance in Human Commensal Escherichia coli over 30 Years in France

• Published in: Applied and environmental microbiology Vol. 88; no. 15; pp. e0066422 - 22
• Main Authors: Marin, Julie, Clermont, Olivier, Royer, Guilhem, Mercier-Darty, Mélanie, Decousser, Jean Winoc, Tenaillon, Olivier, Denamur, Erick, Blanquart, François
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 09.08.2022
• Subjects: Aged; Animals; Antibiotic resistance; Antibiotics; Antigens; Bacteriology; Biodiversity; Drug resistance; Drug Resistance, Multiple, Bacterial - genetics; E coli; Escherichia coli; Escherichia coli Infections; Escherichia coli Infections - epidemiology; Escherichia coli Infections - microbiology; Evolution; Evolutionary and Genomic Microbiology; Evolutionary genetics; Feces; Gene frequency; Genes; Genetics; Genomics; Humans; Infections; Intestine; Life Sciences; Metagenomics; Microbiology and Parasitology; Phylogeny; Populations and Evolution; Prospective Studies; Serotypes; Spotlight Selection; Virulence; Virulence - genetics; Virulence Factors - genetics; France; genomics; commensal; evolution; virulence; antibiotic resistance; Escherichia coli

Escherichia coli is an opportunistic pathogen with the greatest burden of antibiotic resistance, one of the main causes of bacterial infections and an increasing concern in an aging population. Deciphering the evolutionary dynamics of virulence and antibiotic resistance in commensal E. coli is impor...