Neurologic complications of cancer therapy

Neurologic side effects of cancer therapy can inhibit treatment, can be dose-limiting and can diminish quality-of-life. Neurotoxicity related to cancer therapy is a common problem in oncology practice and in clinical neurology. Recognition of neurologic complications of anticancer therapy is necessa...

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Bibliographic Details
Main Authors Wen, Patrick Y, Schiff, David, Lee, Eudocia Quant
Format eBook
LanguageEnglish
Published New York Springer Publishing Company 2011
Springer Publishing Company, Incorporated
Demos
Demos Medical Publishing
demos Medical
Edition1
Subjects
adverse effects
Cancer
Complications
MEDICAL / Oncology
Neoplasms
Neurologic Manifestations
Neurologic manifestations of general diseases
Therapeutics
therapy
Treatment
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Table of Contents:
  • Neurologic complications of cancer therapy -- Dedication -- Contents -- Preface -- Acknowledgments -- Contributors -- Part One: Neurologic Complications of Systematic Therapies According to Agent -- Chapter 1: Neurologic Complications of Alkylating Agent Chemotherapy -- Chapter 2: Neurologic Complications of Antimetabolites -- Chapter 3: Neurologic Complications Associated with Plant Alkaloids -- Chapter 4: Neurologic Complications of Topoisomerase Inhibitors -- Chapter 5: Neurologic Complications of Epothilones and Amino Acid Degraders -- Chapter 6: Neurologic Complications of Corticosteroids -- Chapter 7: Neurologic Complications of Immunomodulatory Agents -- Chapter 8: Neurologic Complications of Immunosuppressive Drugs -- Chapter 9: Neurologic Complications Associated with Biologic Agents -- Chapter 10: Neurologic Complications of Targeted Therapy -- Chapter 11: Neurologic Complications of Hormonal Chemotherapies -- Chapter 12: Neurologic Complications Associated with Supportive Therapies -- Chapter 13: Chemotherapy-Associated Cognitive Dysfunction -- Chapter 14: Central Nervous System Toxicity of Chemotherapy -- Chapter 15: Neurologic Complications Affecting Peripheral Nerves -- Chapter 16: Neurologic Complications Affecting the Neuromuscular Junction -- Part Two: Neurologic Complications of Radiation Therapy -- Chapter 17: Cellular Mechanisms of Radiation Injury to Cognition -- Chapter 18: Central Nervous System Complications of Radiation Therapy -- Chapter 19: Radiation-Induced Tumors -- Chapter 20: Radiation Vasculopathy -- Chapter 21: Radiation Myelopathy -- Chapter 22: Radiation-Induced Peripheral Nerve Disorders -- Part Three: Neurologic Complications of Surgery -- Chapter 23: Complications of Neurosurgical Oncology -- Part Four: Neurologic Complications of Hematopoietic Stem Cell Trasplantation -- Chapter 24: Common Neurologic Complications in Hematopoietic Stem Cell Transplant Patients -- Index.
  • Mammalian Target of Rapamycin Inhibitors: Sirolimus, Everolimus -- Interleukin-2 -- Interferon-Alpha -- Muromonab -- Levamisole -- Antitimor Necrosis Factor-Alpha -- Mycophenolate Mofetil -- Progressive Multifocal Leukoencephalopathy and Immunosuppressives -- References -- Chapter 9: Neurologic Complications Associated with Biologic Agents -- Aldesleukin (Interleukin-2 [IL-2]) -- INTERFERON-α (α-INTERFERON, IFN-α, INTERFERON-α 2A, ROFERON INTERFERON-α 2B, INTRON A) -- Denileukin Diftitox (DAB389) -- Colony-Stimulating Factors: Erythropoietins (Erythropoietin Alfa, Darbepoetin Alfa), Granulocyte Colony- Stimulating Factors (Filgrastim, Pegfilgrastim), and Granulocyte- Macrophage Colonystimulating Factor (Sargramostim) -- Alemtuzumab -- Bevacizumab -- Epidermal Growth Factor Receptor-Directed Monoclonal Antibodies: Cetuximab, Panitumumab -- CD33-Directed Monoclonal Antibodies: Gemtuzumab Ozogamicin (CMA-676) -- CD20-Directed Monoclonal Antibodies: Rituximab, Ibritumomab (IDEC-Y2B8), Tositumomab -- Trastuzumab (Anti-HER2 Antibody) -- References -- Additional Reading -- Chapter 10: Neurologic Complications of Targeted Therapy -- Small Molecular Protein Kinase Inhibitors -- Monoclonal Antibodies -- Antiangiogenic Agents -- References -- Chapter 11: Neurologic Complications of Hormonal Chemotherapies -- Aminoglutethimide -- Anastrozole -- Corticosteroids -- Danazol -- Fulvestrant -- Goserelin -- Letrozole -- Leuprolide Acetate -- Mitotane -- Octreotide -- Tamoxifen -- Toremifine Citrate -- References -- Chapter 12: Neurologic Complications Associated with Supportive Therapies -- Analgesics -- Antiemetics and Neuroleptics -- Anticonvulsants -- Antidepressants -- Anticoagulants -- Psychostimulants -- Antibiotics -- References -- Chapter 13: Chemotherapy-Associated Cognitive Dysfunction -- Epidemiology -- Clinical Presentation
  • Pathogenesis, Mechanisms, and Risk Factors -- Diagnosis -- Treatment -- Summary and Outlook -- Acknowledgments -- References -- Chapter 14: Central Nervous System Toxicity of Chemotherapy -- Headache -- Seizures -- Vascular Complications -- Acute Encephalopathy (Delirium) -- Chronic Encephalopathy (Dementia) -- Movement Disorders -- Cranial Neurophaties -- Myelopathy -- References -- Chapter 15: Neurologic Complications Affecting Peripheral Nerves -- Epidemiology -- Pathophysiology -- Clinical Features -- Diagnosis -- Treatment -- References -- Chapter 16: Neurologic Complications Affecting the Neuromuscular Junction -- Neuromuscular Junction -- Muscle -- Conclusion -- References -- Part Two: Neurologic Complications of Radiation Therapy -- Chapter 17: Cellular Mechanisms of Radiation Injury to Cognition -- Neural Precursor Cells in the Childhood and Adult Brain -- Hippocampal Neurogenesis and Cognition -- Microenvironmental Determinants of Neurogenesis -- The Cellular Basis of Radiation-Induced Cognitive Dysfunction -- Summary -- References -- Chapter 18: Central Nervous System Complications of Radiation Therapy -- Pathophysiology -- Clinical Features -- Conclusion -- References -- Chapter 19: Radiation-Induced Tumors -- Radiation-Induced Menngiomas -- Radiation-Induced Gliomas -- Radiation-Induced Sarcomas -- Radiation-Induced Peripheral Nerve Sheath Tumors -- Radiation-Induced Vascular Lesions -- Conclusion -- Acknowledgments -- References -- Chapter 20: Radiation Vasculopathy -- Radiation-Related Extracranial Vascular Disease -- Intracranial Stenosis/Infarction -- Brain Aneurysms / Pseudoaneurysms / Cavernous Malformations -- Miscellaneous -- References -- Chapter 21: Radiation Myelopathy -- Epidemiology -- Pathophysiology -- Clinical Features -- Diagnosis -- Prognosis and Treatment -- Conclusion -- References
  • Neurologic Complications of Cancer Therapy -- Half Title -- Title Page -- Copyright -- Dedication -- Contents -- Preface -- Acknowledgments -- Contributors -- Part One: Neurologic Complications of Systematic Therapies According to Agent -- Chapter 1: Neurologic Complications of Alkylating Agent Chemotherapy -- Mechanisms of Action -- Mechanisms of Resistance -- Metabolism -- Neurologic Complications of Alkylating Agents -- Conclusion -- Acknowledgments -- References -- Chapter 2: Neurologic Complications of Antimetabolites -- Antifolates -- Cytidine Analogs -- Pyrimidine Analogs -- Adenosine Analogs -- References -- Chapter 3: Neurologic Complications Associated with Plant Alkaloids -- Taxanes (Paclitaxel and Docetaxel) -- Vinca Alkaloids (Vinblastine, Vincristine, and Vinorelbine) -- Podophyllins (Etoposide and Teniposide) -- Camptothecan Analogs (Irinotecan and Topotecan) -- References -- Chapter 4: Neurologic Complications of Topoisomerase Inhibitors -- Topoisomerase I Inhibitors -- Topoisomerase II Inhibitors -- References -- Chapter 5: Neurologic Complications of Epothilones and Amino Acid Degraders -- Epothilones -- Amino Acid Degraders -- References -- Chapter 6: Neurologic Complications of Corticosteroids -- Mechanisms of Action -- Mechanisms of Resistance -- Metabolism of Glucocorticoids -- Common Therapeutic Uses -- Common Therapeutic Regimens -- Common Nonneurologic Clinical Toxicities -- Central Nervous System Effects -- Peripheral Nervous System Effects -- Treatment for Toxicities -- Future Directions and Investigations -- Summary -- References -- Chapter 7: Neurologic Complications of Immunomodulatory Agents -- Tumor Necrosis Factor Alpha -- Interferon Alpha -- Interleukin-2 -- Thalidomide -- Active Immunotherapy -- References -- Chapter 8: Neurologic Complications of Immunosuppressive Drugs -- Calcineurin Inhibitors
  • Chapter 22: Radiation-Induced Peripheral Nerve Disorders -- Radiation-Induced Plexopathies -- Neurotoxicity of Intraoperative Radiotherapy -- Radiation-Induced Multiple or Isolated Mononeurophaties -- Radiation-Induced Peripheral Nerve Tumors -- Conclusion -- References -- Part Three: Neurologic Complications of Surgery -- Chapter 23: Complications of Neurosurgical Oncology -- Neurologic Complications -- Regional Complications -- Medical Complications -- References -- Part Four: Neurologic Complications of Hematopoietic Stem Cell Trasplantation -- Chapter 24: Common Neurologic Complications in Hematopoietic Stem Cell Transplant Patients -- Encephalopathy -- Infections -- Cerebrovascular Disorders -- Conclusion -- References -- Index