Neurologic complications of cancer therapy
Neurologic side effects of cancer therapy can inhibit treatment, can be dose-limiting and can diminish quality-of-life. Neurotoxicity related to cancer therapy is a common problem in oncology practice and in clinical neurology. Recognition of neurologic complications of anticancer therapy is necessa...
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Main Authors | , , |
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Format | eBook |
Language | English |
Published |
New York
Springer Publishing Company
2011
Springer Publishing Company, Incorporated Demos Demos Medical Publishing demos Medical |
Edition | 1 |
Subjects | |
Online Access | Get full text |
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Table of Contents:
- Neurologic complications of cancer therapy -- Dedication -- Contents -- Preface -- Acknowledgments -- Contributors -- Part One: Neurologic Complications of Systematic Therapies According to Agent -- Chapter 1: Neurologic Complications of Alkylating Agent Chemotherapy -- Chapter 2: Neurologic Complications of Antimetabolites -- Chapter 3: Neurologic Complications Associated with Plant Alkaloids -- Chapter 4: Neurologic Complications of Topoisomerase Inhibitors -- Chapter 5: Neurologic Complications of Epothilones and Amino Acid Degraders -- Chapter 6: Neurologic Complications of Corticosteroids -- Chapter 7: Neurologic Complications of Immunomodulatory Agents -- Chapter 8: Neurologic Complications of Immunosuppressive Drugs -- Chapter 9: Neurologic Complications Associated with Biologic Agents -- Chapter 10: Neurologic Complications of Targeted Therapy -- Chapter 11: Neurologic Complications of Hormonal Chemotherapies -- Chapter 12: Neurologic Complications Associated with Supportive Therapies -- Chapter 13: Chemotherapy-Associated Cognitive Dysfunction -- Chapter 14: Central Nervous System Toxicity of Chemotherapy -- Chapter 15: Neurologic Complications Affecting Peripheral Nerves -- Chapter 16: Neurologic Complications Affecting the Neuromuscular Junction -- Part Two: Neurologic Complications of Radiation Therapy -- Chapter 17: Cellular Mechanisms of Radiation Injury to Cognition -- Chapter 18: Central Nervous System Complications of Radiation Therapy -- Chapter 19: Radiation-Induced Tumors -- Chapter 20: Radiation Vasculopathy -- Chapter 21: Radiation Myelopathy -- Chapter 22: Radiation-Induced Peripheral Nerve Disorders -- Part Three: Neurologic Complications of Surgery -- Chapter 23: Complications of Neurosurgical Oncology -- Part Four: Neurologic Complications of Hematopoietic Stem Cell Trasplantation -- Chapter 24: Common Neurologic Complications in Hematopoietic Stem Cell Transplant Patients -- Index.
- Mammalian Target of Rapamycin Inhibitors: Sirolimus, Everolimus -- Interleukin-2 -- Interferon-Alpha -- Muromonab -- Levamisole -- Antitimor Necrosis Factor-Alpha -- Mycophenolate Mofetil -- Progressive Multifocal Leukoencephalopathy and Immunosuppressives -- References -- Chapter 9: Neurologic Complications Associated with Biologic Agents -- Aldesleukin (Interleukin-2 [IL-2]) -- INTERFERON-α (α-INTERFERON, IFN-α, INTERFERON-α 2A, ROFERON INTERFERON-α 2B, INTRON A) -- Denileukin Diftitox (DAB389) -- Colony-Stimulating Factors: Erythropoietins (Erythropoietin Alfa, Darbepoetin Alfa), Granulocyte Colony- Stimulating Factors (Filgrastim, Pegfilgrastim), and Granulocyte- Macrophage Colonystimulating Factor (Sargramostim) -- Alemtuzumab -- Bevacizumab -- Epidermal Growth Factor Receptor-Directed Monoclonal Antibodies: Cetuximab, Panitumumab -- CD33-Directed Monoclonal Antibodies: Gemtuzumab Ozogamicin (CMA-676) -- CD20-Directed Monoclonal Antibodies: Rituximab, Ibritumomab (IDEC-Y2B8), Tositumomab -- Trastuzumab (Anti-HER2 Antibody) -- References -- Additional Reading -- Chapter 10: Neurologic Complications of Targeted Therapy -- Small Molecular Protein Kinase Inhibitors -- Monoclonal Antibodies -- Antiangiogenic Agents -- References -- Chapter 11: Neurologic Complications of Hormonal Chemotherapies -- Aminoglutethimide -- Anastrozole -- Corticosteroids -- Danazol -- Fulvestrant -- Goserelin -- Letrozole -- Leuprolide Acetate -- Mitotane -- Octreotide -- Tamoxifen -- Toremifine Citrate -- References -- Chapter 12: Neurologic Complications Associated with Supportive Therapies -- Analgesics -- Antiemetics and Neuroleptics -- Anticonvulsants -- Antidepressants -- Anticoagulants -- Psychostimulants -- Antibiotics -- References -- Chapter 13: Chemotherapy-Associated Cognitive Dysfunction -- Epidemiology -- Clinical Presentation
- Pathogenesis, Mechanisms, and Risk Factors -- Diagnosis -- Treatment -- Summary and Outlook -- Acknowledgments -- References -- Chapter 14: Central Nervous System Toxicity of Chemotherapy -- Headache -- Seizures -- Vascular Complications -- Acute Encephalopathy (Delirium) -- Chronic Encephalopathy (Dementia) -- Movement Disorders -- Cranial Neurophaties -- Myelopathy -- References -- Chapter 15: Neurologic Complications Affecting Peripheral Nerves -- Epidemiology -- Pathophysiology -- Clinical Features -- Diagnosis -- Treatment -- References -- Chapter 16: Neurologic Complications Affecting the Neuromuscular Junction -- Neuromuscular Junction -- Muscle -- Conclusion -- References -- Part Two: Neurologic Complications of Radiation Therapy -- Chapter 17: Cellular Mechanisms of Radiation Injury to Cognition -- Neural Precursor Cells in the Childhood and Adult Brain -- Hippocampal Neurogenesis and Cognition -- Microenvironmental Determinants of Neurogenesis -- The Cellular Basis of Radiation-Induced Cognitive Dysfunction -- Summary -- References -- Chapter 18: Central Nervous System Complications of Radiation Therapy -- Pathophysiology -- Clinical Features -- Conclusion -- References -- Chapter 19: Radiation-Induced Tumors -- Radiation-Induced Menngiomas -- Radiation-Induced Gliomas -- Radiation-Induced Sarcomas -- Radiation-Induced Peripheral Nerve Sheath Tumors -- Radiation-Induced Vascular Lesions -- Conclusion -- Acknowledgments -- References -- Chapter 20: Radiation Vasculopathy -- Radiation-Related Extracranial Vascular Disease -- Intracranial Stenosis/Infarction -- Brain Aneurysms / Pseudoaneurysms / Cavernous Malformations -- Miscellaneous -- References -- Chapter 21: Radiation Myelopathy -- Epidemiology -- Pathophysiology -- Clinical Features -- Diagnosis -- Prognosis and Treatment -- Conclusion -- References
- Neurologic Complications of Cancer Therapy -- Half Title -- Title Page -- Copyright -- Dedication -- Contents -- Preface -- Acknowledgments -- Contributors -- Part One: Neurologic Complications of Systematic Therapies According to Agent -- Chapter 1: Neurologic Complications of Alkylating Agent Chemotherapy -- Mechanisms of Action -- Mechanisms of Resistance -- Metabolism -- Neurologic Complications of Alkylating Agents -- Conclusion -- Acknowledgments -- References -- Chapter 2: Neurologic Complications of Antimetabolites -- Antifolates -- Cytidine Analogs -- Pyrimidine Analogs -- Adenosine Analogs -- References -- Chapter 3: Neurologic Complications Associated with Plant Alkaloids -- Taxanes (Paclitaxel and Docetaxel) -- Vinca Alkaloids (Vinblastine, Vincristine, and Vinorelbine) -- Podophyllins (Etoposide and Teniposide) -- Camptothecan Analogs (Irinotecan and Topotecan) -- References -- Chapter 4: Neurologic Complications of Topoisomerase Inhibitors -- Topoisomerase I Inhibitors -- Topoisomerase II Inhibitors -- References -- Chapter 5: Neurologic Complications of Epothilones and Amino Acid Degraders -- Epothilones -- Amino Acid Degraders -- References -- Chapter 6: Neurologic Complications of Corticosteroids -- Mechanisms of Action -- Mechanisms of Resistance -- Metabolism of Glucocorticoids -- Common Therapeutic Uses -- Common Therapeutic Regimens -- Common Nonneurologic Clinical Toxicities -- Central Nervous System Effects -- Peripheral Nervous System Effects -- Treatment for Toxicities -- Future Directions and Investigations -- Summary -- References -- Chapter 7: Neurologic Complications of Immunomodulatory Agents -- Tumor Necrosis Factor Alpha -- Interferon Alpha -- Interleukin-2 -- Thalidomide -- Active Immunotherapy -- References -- Chapter 8: Neurologic Complications of Immunosuppressive Drugs -- Calcineurin Inhibitors
- Chapter 22: Radiation-Induced Peripheral Nerve Disorders -- Radiation-Induced Plexopathies -- Neurotoxicity of Intraoperative Radiotherapy -- Radiation-Induced Multiple or Isolated Mononeurophaties -- Radiation-Induced Peripheral Nerve Tumors -- Conclusion -- References -- Part Three: Neurologic Complications of Surgery -- Chapter 23: Complications of Neurosurgical Oncology -- Neurologic Complications -- Regional Complications -- Medical Complications -- References -- Part Four: Neurologic Complications of Hematopoietic Stem Cell Trasplantation -- Chapter 24: Common Neurologic Complications in Hematopoietic Stem Cell Transplant Patients -- Encephalopathy -- Infections -- Cerebrovascular Disorders -- Conclusion -- References -- Index