In Vitro Susceptibility of Leishmania infantum to Artemisinin Derivatives and Selected Trioxolanes

• Published in: Antimicrobial agents and chemotherapy Vol. 59; no. 8; pp. 5032 - 5035
• Main Authors: Cortes, Sofia, Albuquerque, Andreia, Cabral, Lília I L, Lopes, Liliana, Campino, Lenea, Cristiano, Maria L S
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.08.2015
• Subjects: Antiparasitic Agents; Antiparasitic Agents - pharmacology; Artemisinins; Artemisinins - pharmacology; Cell Proliferation - drug effects; Drug Resistance, Multiple; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 1-Ring - pharmacology; Humans; Leishmania infantum; Leishmania infantum - drug effects; Leishmaniasis; Leishmaniasis - drug therapy; Macrophages - parasitology; Parasitic Sensitivity Tests; Spiro Compounds; Spiro Compounds - pharmacology; Susceptibility

Leishmaniasis is among the world's most neglected diseases. Currently available drugs for treatment present drawbacks, urging the need for more effective, safer, and cheaper drugs. A small library of artemisinin-derived trioxanes and synthetic trioxolanes was tested against promastigote and int...