Diffusion in Low-Dimensional Lipid Membranes

The diffusion behavior of biological components in cellular membranes is vital to the function of cells. By collapsing the complexity of planar 2D membranes down to one dimension, fundamental investigations of bimolecular behavior become possible in one dimension. Here we develop lipid nanolithograp...

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Published inNano letters Vol. 14; no. 10; pp. 5984 - 5988
Main Authors Heath, George R, Roth, Johannes, Connell, Simon D, Evans, Stephen D
Format Journal Article
LanguageEnglish
Published Washington, DC American Chemical Society 08.10.2014
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Abstract The diffusion behavior of biological components in cellular membranes is vital to the function of cells. By collapsing the complexity of planar 2D membranes down to one dimension, fundamental investigations of bimolecular behavior become possible in one dimension. Here we develop lipid nanolithography methods to produce membranes, under fluid, with widths as low as 6 nm but extending to microns in length. We find reduced lipid mobility, as the width is reduced below 50 nm, suggesting different lipid packing in the vicinity of boundaries. The insertion of a membrane protein, M2, into these systems, allowed characterization of protein diffusion using high-speed AFM to demonstrate the first membrane protein 1D random walk. These quasi-1D lipid bilayers are ideal for testing and understanding fundamental concepts about the roles of dimensionality and size on physical properties of membranes from energy transfer to lipid packing.
AbstractList The diffusion behavior of biological components in cellular membranes is vital to the function of cells. By collapsing the complexity of planar 2D membranes down to one dimension, fundamental investigations of bimolecular behavior become possible in one dimension. Here we develop lipid nanolithography methods to produce membranes, under fluid, with widths as low as 6 nm but extending to microns in length. We find reduced lipid mobility, as the width is reduced below 50 nm, suggesting different lipid packing in the vicinity of boundaries. The insertion of a membrane protein, M2, into these systems, allowed characterization of protein diffusion using high-speed AFM to demonstrate the first membrane protein 1D random walk. These quasi-1D lipid bilayers are ideal for testing and understanding fundamental concepts about the roles of dimensionality and size on physical properties of membranes from energy transfer to lipid packing. Keywords: Lipid membranes; high-speed AFM; nanolithography; molecular crowding; lipid diffusion
The diffusion behavior of biological components in cellular membranes is vital to the function of cells. By collapsing the complexity of planar 2D membranes down to one dimension, fundamental investigations of bimolecular behavior become possible in one dimension. Here we develop lipid nanolithography methods to produce membranes, under fluid, with widths as low as 6 nm but extending to microns in length. We find reduced lipid mobility, as the width is reduced below 50 nm, suggesting different lipid packing in the vicinity of boundaries. The insertion of a membrane protein, M2, into these systems, allowed characterization of protein diffusion using high-speed AFM to demonstrate the first membrane protein 1D random walk. These quasi-1D lipid bilayers are ideal for testing and understanding fundamental concepts about the roles of dimensionality and size on physical properties of membranes from energy transfer to lipid packing.
Author Connell, Simon D
Evans, Stephen D
Roth, Johannes
Heath, George R
AuthorAffiliation University of Leeds
School of Physics and Astronomy
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  email: s.d.evans@leeds.ac.uk
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Cites_doi 10.1038/nature06531
10.1080/00268949108035656
10.1038/nature04164
10.1039/b704827k
10.1126/science.1119238
10.1021/ja100294k
10.1021/ja503138p
10.1038/nnano.2008.398
10.1021/ja077730s
10.1146/annurev.biochem.72.121801.161504
10.1016/S0006-3495(76)85755-4
10.1021/la00011a058
10.1007/s101890070039
10.1016/j.bpj.2010.09.032
10.1002/sca.20166
10.1021/ac201768k
10.1529/biophysj.103.036111
10.1529/biophysj.103.031054
10.1007/s100510050862
10.1038/nnano.2010.17
10.1021/ja2007615
10.1002/smll.200600431
10.1021/jp400371k
10.1021/la9903043
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Issue 10
Keywords lipid diffusion
Lipid membranes
nanolithography
high-speed AFM
molecular crowding
Atomic force microscopy
Dimensionality
Macromolecules
Lipids
Diffusion
Nanolithography
Physical properties
Energy transfer
Lipid bilayers
Membrane proteins
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References West A. (ref20/cit20) 2013; 117
Mossman K. D. (ref3/cit3) 2005; 310
Nissen J. (ref16/cit16) 1999; 10
Portet T. (ref15/cit15) 2010; 99
May S. (ref11/cit11) 2000; 3
Sanii B. (ref17/cit17) 2007; 3
Lenhert S. (ref8/cit8) 2007; 3
Axelrod D. (ref19/cit19) 1976; 16
Liu C. (ref4/cit4) 2011; 83
Tanaka M. (ref2/cit2) 2005; 437
Lenhert S. (ref7/cit7) 2010; 32
Shi J. (ref10/cit10) 2008; 130
Hughes T. (ref24/cit24) 2004; 87
Braun T. (ref1/cit1) 2009; 4
Schnell J. R. (ref23/cit23) 2008; 451
Smith A. M. (ref22/cit22) 2010; 132
Jiang F. Y. (ref21/cit21) 2004; 87
Lenhert S. (ref9/cit9) 2010; 5
Chernomordik L. V. (ref12/cit12) 2003; 72
Radu V. (ref6/cit6) 2014
Casuso I. (ref25/cit25) 2012
Lipowsky R. (ref13/cit13) 1991; 202
Rädler J. (ref18/cit18) 1995; 11
Cheetham M. R. (ref5/cit5) 2011; 133
Reviakine I. (ref14/cit14) 2000; 16
References_xml – volume: 451
  start-page: 591
  year: 2008
  ident: ref23/cit23
  publication-title: Nature
  doi: 10.1038/nature06531
  contributor:
    fullname: Schnell J. R.
– volume: 202
  start-page: 17
  year: 1991
  ident: ref13/cit13
  publication-title: Mol. Cryst. Liq. Cryst.
  doi: 10.1080/00268949108035656
  contributor:
    fullname: Lipowsky R.
– volume: 437
  start-page: 656
  year: 2005
  ident: ref2/cit2
  publication-title: Nature
  doi: 10.1038/nature04164
  contributor:
    fullname: Tanaka M.
– volume: 3
  start-page: 974
  year: 2007
  ident: ref17/cit17
  publication-title: Soft Matter
  doi: 10.1039/b704827k
  contributor:
    fullname: Sanii B.
– volume: 310
  start-page: 1191
  year: 2005
  ident: ref3/cit3
  publication-title: Science
  doi: 10.1126/science.1119238
  contributor:
    fullname: Mossman K. D.
– volume: 132
  start-page: 9320
  year: 2010
  ident: ref22/cit22
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja100294k
  contributor:
    fullname: Smith A. M.
– start-page: 8512
  year: 2014
  ident: ref6/cit6
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja503138p
  contributor:
    fullname: Radu V.
– volume: 4
  start-page: 179
  year: 2009
  ident: ref1/cit1
  publication-title: Nat. Nanotechnol.
  doi: 10.1038/nnano.2008.398
  contributor:
    fullname: Braun T.
– volume: 130
  start-page: 2718
  year: 2008
  ident: ref10/cit10
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja077730s
  contributor:
    fullname: Shi J.
– volume: 72
  start-page: 175
  year: 2003
  ident: ref12/cit12
  publication-title: Annu. Rev. Biochem.
  doi: 10.1146/annurev.biochem.72.121801.161504
  contributor:
    fullname: Chernomordik L. V.
– volume: 16
  start-page: 1055
  year: 1976
  ident: ref19/cit19
  publication-title: Biophys. J.
  doi: 10.1016/S0006-3495(76)85755-4
  contributor:
    fullname: Axelrod D.
– volume: 11
  start-page: 4539
  year: 1995
  ident: ref18/cit18
  publication-title: Langmuir
  doi: 10.1021/la00011a058
  contributor:
    fullname: Rädler J.
– volume: 3
  start-page: 37
  year: 2000
  ident: ref11/cit11
  publication-title: Eur. Phys. J. E
  doi: 10.1007/s101890070039
  contributor:
    fullname: May S.
– volume: 99
  start-page: 3264
  year: 2010
  ident: ref15/cit15
  publication-title: Biophys. J.
  doi: 10.1016/j.bpj.2010.09.032
  contributor:
    fullname: Portet T.
– volume: 32
  start-page: 15
  year: 2010
  ident: ref7/cit7
  publication-title: Scanning
  doi: 10.1002/sca.20166
  contributor:
    fullname: Lenhert S.
– volume: 83
  start-page: 7876
  year: 2011
  ident: ref4/cit4
  publication-title: Anal. Chem.
  doi: 10.1021/ac201768k
  contributor:
    fullname: Liu C.
– volume: 87
  start-page: 311
  year: 2004
  ident: ref24/cit24
  publication-title: Biophys. J.
  doi: 10.1529/biophysj.103.036111
  contributor:
    fullname: Hughes T.
– volume: 87
  start-page: 182
  year: 2004
  ident: ref21/cit21
  publication-title: Biophys. J.
  doi: 10.1529/biophysj.103.031054
  contributor:
    fullname: Jiang F. Y.
– volume: 10
  start-page: 335
  year: 1999
  ident: ref16/cit16
  publication-title: Eur. Phys. J. B: Condens. Matter Complex Syst.
  doi: 10.1007/s100510050862
  contributor:
    fullname: Nissen J.
– start-page: 1
  year: 2012
  ident: ref25/cit25
  publication-title: Nat. Nanotechnol.
  contributor:
    fullname: Casuso I.
– volume: 5
  start-page: 275
  year: 2010
  ident: ref9/cit9
  publication-title: Nat. Nanotechnol.
  doi: 10.1038/nnano.2010.17
  contributor:
    fullname: Lenhert S.
– volume: 133
  start-page: 6521
  year: 2011
  ident: ref5/cit5
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja2007615
  contributor:
    fullname: Cheetham M. R.
– volume: 3
  start-page: 71
  year: 2007
  ident: ref8/cit8
  publication-title: Small
  doi: 10.1002/smll.200600431
  contributor:
    fullname: Lenhert S.
– volume: 117
  start-page: 7114
  year: 2013
  ident: ref20/cit20
  publication-title: J. Phys. Chem. A
  doi: 10.1021/jp400371k
  contributor:
    fullname: West A.
– volume: 16
  start-page: 1806
  year: 2000
  ident: ref14/cit14
  publication-title: Langmuir
  doi: 10.1021/la9903043
  contributor:
    fullname: Reviakine I.
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Snippet The diffusion behavior of biological components in cellular membranes is vital to the function of cells. By collapsing the complexity of planar 2D membranes...
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SubjectTerms Atomic force microscopy
Condensed matter: structure, mechanical and thermal properties
Cross-disciplinary physics: materials science; rheology
Diffusion
Diffusion in nanoscale solids
Diffusion in solids
Electron, ion, and scanning probe microscopy
Exact sciences and technology
High speed
Humans
Influenza A virus - chemistry
Influenza, Human - virology
Lipid Bilayers - chemistry
Lipids
Materials science
Membranes
Methods of nanofabrication
Microscopy, Atomic Force
Models, Molecular
Nanolithography
Nanostructure
Nanotechnology
Phosphatidylcholines - chemistry
Phosphatidylethanolamines - chemistry
Physics
Proteins
Scanning probe microscopy: scanning tunneling, atomic force, scanning optical, magnetic force, etc
Structure of solids and liquids; crystallography
Transport properties of condensed matter (nonelectronic)
Viral Matrix Proteins - chemistry
Title Diffusion in Low-Dimensional Lipid Membranes
URI http://dx.doi.org/10.1021/nl503024v
https://www.ncbi.nlm.nih.gov/pubmed/25166509
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Volume 14
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