Anticancer Drugs of Lysine Specific Histone Demethylase‑1 (LSD1) Display Variable Inhibition on Nucleosome Substrates - Senanayaka, Dulmi; Zeng, Danyun; Deniz, Emre; Priyankara, Indunil K.; Helmbreck, Joceline; Schneider, Owen; Mardikar, Aashay; Uren, Aykut; Reiter, Nicholas J. (Biochemistry (Easton), 2024)
Keywords: Antineoplastic Agents - pharmacology; Cell Line, Tumor; cytotoxicity; demethylation; drugs; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - pharmacology; enzymes; epigenetics; Histone Demethylases - antagonists & inhibitors; Histone Demethylases - metabolism; histones; Histones - metabolism; Humans; Kinetics; lung neoplasms; lysine; mechanism of action; myeloid leukemia; nucleosomes; Nucleosomes - drug effects; Nucleosomes - metabolism; peptides; sarcoma; Substrate Specificity; Tranylcypromine - pharmacology; viability; Western blotting