Interdomain and Intermodule Organization in Epimerization Domain Containing Nonribosomal Peptide Synthetases

• Published in: ACS chemical biology Vol. 11; no. 8; pp. 2293 - 2303
• Main Authors: Chen, Wei-Hung, Li, Kunhua, Guntaka, Naga Sandhya, Bruner, Steven D
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 19.08.2016; American Chemical Society (ACS)
• Subjects: BASIC BIOLOGICAL SCIENCES; Catalytic Domain; Chemical structure; Crystal structure; Crystallography, X-Ray; Diketopiperazines - chemistry; INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; Interfaces; Isomerism; Monomers; Mutagenesis, Site-Directed; Peptide Synthases - chemistry; Peptide Synthases - genetics; Peptide Synthases - metabolism; Peptides and proteins; Protein Conformation

Nonribosomal peptide synthetases are large, complex multidomain enzymes responsible for the biosynthesis of a wide range of peptidic natural products. Inherent to synthetase chemistry is the thioester templated mechanism that relies on protein/protein interactions and interdomain dynamics. Several q...