C1‘-Cycloalkyl Side Chain Pharmacophore in Tetrahydrocannabinols

In earlier work we have provided evidence for the presence of a subsite within the CB1 and CB2 cannabinoid receptor binding domains of classical cannabinoids. This putative subsite corresponds to substituents on the C1‘-position of the C3-alkyl side chain, a key pharmacophoric feature in this class...

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Published inJournal of medicinal chemistry Vol. 50; no. 17; pp. 4048 - 4060
Main Authors Papahatjis, Demetris P, Nahmias, Victoria R, Nikas, Spyros P, Andreou, Thanos, Alapafuja, Shakiru O, Tsotinis, Andrew, Guo, Jianxin, Fan, Pusheng, Makriyannis, Alexandros
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 23.08.2007
Amer Chemical Soc
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