Global Profiling of Cellular Substrates of Human Dcp2

• Published in: Biochemistry (Easton) Vol. 59; no. 43; pp. 4176 - 4188
• Main Authors: Luo, Yang, Schofield, Jeremy A, Simon, Matthew D, Slavoff, Sarah A
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 03.11.2020
• Subjects: additive effect; Animals; cells; consensus sequence; cytoplasm; Cytoplasm - genetics; Cytoplasm - metabolism; deterioration; Endoribonucleases - genetics; Endoribonucleases - metabolism; enzyme substrates; enzymes; exhibitions; Humans; Models, Biological; RNA; RNA Stability - genetics; RNA Stability - physiology; transcriptome; Transcriptome - genetics; Transcriptome - physiology; translation (genetics)

Decapping is the first committed step in 5′-to-3′ RNA decay, and in the cytoplasm of human cells, multiple decapping enzymes regulate the stabilities of distinct subsets of cellular transcripts. However, the complete set of RNAs regulated by any individual decapping enzyme remains incompletely mappe...