Gray Matter Volume Abnormalities in ADHD: Voxel-Based Meta-Analysis Exploring the Effects of Age and Stimulant Medication

• Published in: The American journal of psychiatry Vol. 168; no. 11; pp. 1154 - 1163
• Main Authors: Nakao, Tomohiro, Radua, Joaquim, Rubia, Katya, Mataix-Cols, David
• Format: Journal Article
• Language: English
• Published: Arlington, VA American Psychiatric Publishing 01.11.2011; American Psychiatric Association
• Subjects: Age; Attention Deficit Disorder with Hyperactivity - drug therapy; Attention Deficit Disorder with Hyperactivity - pathology; Attention deficit hyperactivity disorder; Biological and medical sciences; Brain; Brain - pathology; Brain Mapping; Central Nervous System Stimulants - pharmacology; Central Nervous System Stimulants - therapeutic use; Humans; Hyperactivity; Medical sciences; Meta-analysis; Nerve Fibers, Unmyelinated - pathology; Neuroimaging; Neuropharmacology; Neuropsychology; Pharmacology. Drug treatments; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Stimulants; Systematic review; CNS stimulant; Psychotropic; Grey matter; Attention disorder with hyperactivity; Review; Age; Metaanalysis

This meta-analysis of brain imaging studies confirmed that gray matter volume deficits are less abnormal for patients taking stimulants and for adults with the disorder. The latter finding suggests that development may “catch up” as the patient ages. Objective:Structural neuroimaging studies in atte...