NosP Signaling Modulates the NO/H-NOX-Mediated Multicomponent c‑Di-GMP Network and Biofilm Formation in Shewanella oneidensis

• Published in: Biochemistry (Easton) Vol. 58; no. 48; pp. 4827 - 4841
• Main Authors: Nisbett, Lisa-Marie, Binnenkade, Lucas, Bacon, Bezalel, Hossain, Sajjad, Kotloski, Nicholas J, Brutinel, Evan D, Hartmann, Raimo, Drescher, Knut, Arora, Dhruv P, Muralidharan, Sandhya, Thormann, Kai M, Gralnick, Jeffrey A, Boon, Elizabeth M
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 03.12.2019
• Subjects: antibiotics; architecture; bacteria; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; biofilm; Biofilms; Cyclic GMP - analogs & derivatives; Cyclic GMP - metabolism; exopolysaccharides; Gene Expression Regulation, Bacterial; Heme - metabolism; mutants; nitric oxide; Nitric Oxide - metabolism; phosphates; protein phosphorylation; proteins; Shewanella - genetics; Shewanella - physiology; Shewanella oneidensis; Signal Transduction; strains

Biofilms form when bacteria aggregate in a self-secreted exopolysaccharide matrix; they are resistant to antibiotics and implicated in disease. Nitric oxide (NO) is known to mediate biofilm formation in many bacteria via ligation to H-NOX (heme-NO/oxygen binding) domains. Most NO-responsive bacteria...