The NBDY Microprotein Regulates Cellular RNA Decapping

• Published in: Biochemistry (Easton) Vol. 59; no. 42; pp. 4131 - 4142
• Main Authors: Na, Zhenkun, Luo, Yang, Schofield, Jeremy A, Smelyansky, Stephanie, Khitun, Alexandra, Muthukumar, Sowndarya, Valkov, Eugene, Simon, Matthew D, Slavoff, Sarah A
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 27.10.2020
• Subjects: amino acids; cell growth; cells; deterioration; geneticists; granules; half life; HEK293 Cells; Humans; length; Nonsense Mediated mRNA Decay - genetics; Nonsense Mediated mRNA Decay - physiology; open reading frames; Open Reading Frames - genetics; polypeptides; reporter genes; ribonucleoproteins; RNA; RNA Caps - chemistry; RNA Caps - metabolism; RNA Stability; RNA, Messenger - chemistry; RNA, Messenger - metabolism; transcriptome

Proteogenomic identification of translated small open reading frames in humans has revealed thousands of microproteins, or polypeptides of fewer than 100 amino acids, that were previously invisible to geneticists. Hundreds of microproteins have been shown to be essential for cell growth and prolifer...