Quaternary Structure of Fur Proteins, a New Subfamily of Tetrameric Proteins

• Published in: Biochemistry (Easton) Vol. 55; no. 10; pp. 1503 - 1515
• Main Authors: Pérard, Julien, Covès, Jacques, Castellan, Mathieu, Solard, Charles, Savard, Myriam, Miras, Roger, Galop, Sandra, Signor, Luca, Crouzy, Serge, Michaud-Soret, Isabelle, de Rosny, Eve
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 15.03.2016
• Subjects: Amino Acid Sequence; Bacterial Proteins - chemistry; Bacterial Proteins - genetics; Bacteriology; Biochemistry, Molecular Biology; case studies; crosslinking; dissociation; DNA; DNA, Bacterial - chemistry; DNA, Bacterial - genetics; Escherichia coli; Escherichia coli - genetics; Francisella tularensis; Francisella tularensis - genetics; gene activation; gene expression; genes; Genomics; iron; iron absorption; Legionella pneumophila; Legionella pneumophila - genetics; Life Sciences; light scattering; Microbiology and Parasitology; Molecular Sequence Data; new subfamily; nucleotide sequences; oxidative stress; Protein Structure, Quaternary - genetics; Protein Structure, Secondary; Pseudomonas aeruginosa; Pseudomonas aeruginosa - genetics; Repressor Proteins - chemistry; Repressor Proteins - genetics; transcription factors; virulence; virulent strains; X-radiation; Yersinia - genetics; Yersinia pestis

The ferric uptake regulator (Fur) belongs to the family of the DNA-binding metal-responsive transcriptional regulators. Fur is a global regulator found in all proteobacteria. It controls the transcription of a wide variety of genes involved in iron metabolism but also in oxidative stress or virulenc...