Recognition of DNA Supercoil Handedness during Catenation Catalyzed by Type II Topoisomerases

• Published in: Biochemistry (Easton) Vol. 61; no. 19; pp. 2148 - 2158
• Main Authors: Dalvie, Esha D., Stacy, Jordan C., Neuman, Keir C., Osheroff, Neil
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 04.10.2022
• Subjects: amino acid sequences; Catalysis; Catenanes; DNA; DNA damage; DNA Topoisomerase IV; DNA Topoisomerases, Type I - genetics; DNA Topoisomerases, Type II - metabolism; DNA, Superhelical; enzymes; Functional Laterality; genomics; geometry; Humans; mitotic spindle apparatus; topology

Although the presence of catenanes (i.e., intermolecular tangles) in chromosomal DNA stabilizes interactions between daughter chromosomes, a lack of resolution can have serious consequences for genomic stability. In all species, from bacteria to humans, type II topoisomerases are the enzymes primari...