Natural Product Micheliolide (MCL) Irreversibly Activates Pyruvate Kinase M2 and Suppresses Leukemia - Li, Jing; Li, Shanshan; Guo, Jianshuang; Li, Qiuying; Long, Jing; Ma, Cheng; Ding, Yahui; Yan, Chunli; Li, Liangwei; Wu, Zhigang; Zhu, He; Li, Keqin Kathy; et al. (Journal of medicinal chemistry, 2018)
Keywords: 60 APPLIED LIFE SCIENCES; Acetylation - drug effects; Active Transport, Cell Nucleus - drug effects; Amino Acid Sequence; Animals; Antineoplastic Agents - pharmacology; Carcinogenesis - drug effects; Carrier Proteins - chemistry; Carrier Proteins - metabolism; Cell Line, Tumor; Cell Nucleus - drug effects; Cell Nucleus - metabolism; Enzyme Activation - drug effects; Gene Expression Regulation, Neoplastic - drug effects; Humans; Leukemia - pathology; Membrane Proteins - chemistry; Membrane Proteins - metabolism; Pharmacology & Pharmacy; Phosphorylation - drug effects; Protein Domains; Protein Multimerization; Protein Structure, Quaternary; Sesquiterpenes, Guaiane - pharmacology; Substrate Specificity; Thyroid Hormone-Binding Proteins; Thyroid Hormones - chemistry; Thyroid Hormones - metabolism; Xenograft Model Antitumor Assays; Zebrafish