Highly Sensitive and Selective Spiropyran-Based Sensor for Copper(II) Quantification

The metal-binding capabilities of the spiropyran family of molecular switches have been explored for several purposes from sensing to optical circuits. Metal-selective sensing has been of great interest for applications ranging from environmental assays to industrial quality control, but sensitive m...

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Published inACS omega Vol. 6; no. 16; pp. 10776 - 10789
Main Authors Trevino, Kimberly M, Tautges, Brandon K, Kapre, Rohan, Franco Jr, Francisco C, Or, Victor W, Balmond, Edward I, Shaw, Jared T, Garcia, Joel, Louie, Angelique Y
Format Journal Article
LanguageEnglish
Published American Chemical Society 27.04.2021
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Abstract The metal-binding capabilities of the spiropyran family of molecular switches have been explored for several purposes from sensing to optical circuits. Metal-selective sensing has been of great interest for applications ranging from environmental assays to industrial quality control, but sensitive metal detection for field-based assays has been elusive. In this work, we demonstrate colorimetric copper sensing at low micromolar levels. Dimethylamine-functionalized spiropyran (SP1) was synthesized and its metal-sensing properties were investigated using UV–vis spectrophotometry. The formation of a metal complex between SP1 and Cu2+ was associated with a color change that can be observed by the naked eye as low as ≈6 μM and the limit of detection was found to be 0.11 μM via UV–vis spectrometry. Colorimetric data showed linearity of response in a physiologically relevant range (0–20 μM Cu2+) with high selectivity for Cu2+ ions over biologically and environmentally relevant metals such as Na+, K+, Mn2+, Ca2+, Zn2+, Co2+, Mg2+, Ni2+, Fe3+, Cd2+, and Pb2+. Since the color change accompanying SP1–Cu2+ complex formation could be detected at low micromolar concentrations, SP1 could be viable for field testing of trace Cu2+ ions.
AbstractList The metal-binding capabilities of the spiropyran family of molecular switches have been explored for several purposes from sensing to optical circuits. Metal-selective sensing has been of great interest for applications ranging from environmental assays to industrial quality control, but sensitive metal detection for field-based assays has been elusive. In this work, we demonstrate colorimetric copper sensing at low micromolar levels. Dimethylamine-functionalized spiropyran ( SP1 ) was synthesized and its metal-sensing properties were investigated using UV–vis spectrophotometry. The formation of a metal complex between SP1 and Cu 2+ was associated with a color change that can be observed by the naked eye as low as ≈6 μM and the limit of detection was found to be 0.11 μM via UV–vis spectrometry. Colorimetric data showed linearity of response in a physiologically relevant range (0–20 μM Cu 2+ ) with high selectivity for Cu 2+ ions over biologically and environmentally relevant metals such as Na + , K + , Mn 2+ , Ca 2+ , Zn 2+ , Co 2+ , Mg 2+ , Ni 2+ , Fe 3+ , Cd 2+ , and Pb 2+ . Since the color change accompanying SP1 –Cu 2+ complex formation could be detected at low micromolar concentrations, SP1 could be viable for field testing of trace Cu 2+ ions.
The metal-binding capabilities of the spiropyran family of molecular switches have been explored for several purposes from sensing to optical circuits. Metal-selective sensing has been of great interest for applications ranging from environmental assays to industrial quality control, but sensitive metal detection for field-based assays has been elusive. In this work, we demonstrate colorimetric copper sensing at low micromolar levels. Dimethylamine-functionalized spiropyran (SP1) was synthesized and its metal-sensing properties were investigated using UV–vis spectrophotometry. The formation of a metal complex between SP1 and Cu2+ was associated with a color change that can be observed by the naked eye as low as ≈6 μM and the limit of detection was found to be 0.11 μM via UV–vis spectrometry. Colorimetric data showed linearity of response in a physiologically relevant range (0–20 μM Cu2+) with high selectivity for Cu2+ ions over biologically and environmentally relevant metals such as Na+, K+, Mn2+, Ca2+, Zn2+, Co2+, Mg2+, Ni2+, Fe3+, Cd2+, and Pb2+. Since the color change accompanying SP1–Cu2+ complex formation could be detected at low micromolar concentrations, SP1 could be viable for field testing of trace Cu2+ ions.
Author Or, Victor W
Louie, Angelique Y
Balmond, Edward I
Garcia, Joel
Shaw, Jared T
Trevino, Kimberly M
Kapre, Rohan
Tautges, Brandon K
Franco Jr, Francisco C
AuthorAffiliation Chemistry Department
University of California at Davis
Department of Biomedical Engineering
Chemistry Graduate Group
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Snippet The metal-binding capabilities of the spiropyran family of molecular switches have been explored for several purposes from sensing to optical circuits....
The metal-binding capabilities of the spiropyran family of molecular switches have been explored for several purposes from sensing to optical circuits....
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Title Highly Sensitive and Selective Spiropyran-Based Sensor for Copper(II) Quantification
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