Telmisartan Mitigates TNF-α-Induced Type II Collagen Reduction by Upregulating SOX‑9

• Published in: ACS omega Vol. 6; no. 17; pp. 11756 - 11761
• Main Authors: Zhang, Xiuying, Dong, Yanfeng, Dong, Hanyu, Cui, Yanhui, Du, Qing, Wang, Xiaoli, Li, Lanlan, Zhang, Hongju
• Format: Journal Article
• Language: English
• Published: American Chemical Society 04.05.2021

The proinflammatory cytokine tumor necrosis factor-α (TNF-α)-induced degradation of extracellular matrix (ECM), such as type II collagen in chondrocytes, plays an important role in the development of osteoarthritis (OA). Telmisartan, an angiotensin II (Ang-II) receptor blocker, is a licensed drug us...