Antibacterial Action of Anacardic Acids against Methicillin Resistant Staphylococcus aureus (MRSA)

The structural and antibacterial activity relationship of 6-alk(en)ylsalicylic acids, also known as anacardic acids, was investigated against Gram-positive bacteria, emphasizing the methicillin resistant Staphylococcus aureus ATCC 33591 (MRSA) strain. The unsaturation in the alkyl side chain is not...

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Bibliographic Details
Published inJournal of agricultural and food chemistry Vol. 51; no. 26; pp. 7624 - 7628
Main Authors Kubo, Isao, Nihei, Ken-ichi, Tsujimoto, Kazuo
Format Journal Article
LanguageEnglish
Published Washington, DC American Chemical Society 17.12.2003
Subjects
Anacardic Acids
Anti-Bacterial Agents - pharmacology
Biological and medical sciences
General pharmacology
Medical sciences
Methicillin - pharmacology
Methicillin Resistance
Penicillin G - pharmacology
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Salicylates - chemistry
Salicylates - pharmacology
Staphylococcus aureus
Staphylococcus aureus - drug effects
Structure-Activity Relationship
Pharmacognosy
methicillin
synergists
Surfactant
Structure function relationship
Synergism
Biological activity
anacardic acids
Antibiotic
surfactants
Plasma membrane
Antibiotic resistance
Bacteria
Micrococcales
Antibacterial activity
Micrococcaceae
Disruption
Inhibition
Antibacterial agent
Staphylococcus aureus
fractional inhibitory concentration (FIC) index
methicillin resistant Staphylococcus aureus (MRSA)
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Summary:The structural and antibacterial activity relationship of 6-alk(en)ylsalicylic acids, also known as anacardic acids, was investigated against Gram-positive bacteria, emphasizing the methicillin resistant Staphylococcus aureus ATCC 33591 (MRSA) strain. The unsaturation in the alkyl side chain is not essential in eliciting activity but is associated with increasing the activity. The antibacterial activity of methicillin against MRSA strains was significantly enhanced in combination with C12:0-anacardic acid, and the fractional inhibitory concentration index for this combination was calculated as 0.281. It appears that biophysical disruption of the membrane (surfactant property) is due to the primary response to their antibacterial activity, while biochemical mechanisms are little involved. The compounds possessing the similar log P values exhibit similar activity. Keywords: Antibacterial activity; methicillin resistant Staphylococcus aureus (MRSA); anacardic acids; surfactants; synergists; methicillin; fractional inhibitory concentration (FIC) index
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ISSN:0021-8561
1520-5118
DOI:10.1021/jf034674f