Nanopore-based Strategy for Selective Detection of Single Carcinoembryonic Antigen (CEA) Molecules

• Published in: Analytical chemistry (Washington) Vol. 92; no. 4; pp. 3042 - 3049
• Main Authors: Tang, Haoran, Wang, Hao, Yang, Cheng, Zhao, Dandan, Qian, Yuanyuan, Li, Yongxin
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 18.02.2020
• Subjects: Antigens; Aptamers; Biomarkers; Biomolecules; Cancer; Carcinoembryonic antigen; Carcinoembryonic Antigen - blood; Chemistry; Detection; detection limit; early diagnosis; Gold; Gold - chemistry; Humans; Iron oxides; Magnetic separation; magnetism; Magnetite Nanoparticles - chemistry; Metal Nanoparticles - chemistry; monitoring; Nanoparticles; Nanopores; neoplasms; oligonucleotides; particle size; Porosity; Selectivity; Sensitivity analysis; Strategy

Nanopores have become one of the most important tools for single-molecule sensing, but the challenge for selective detection of specific biomolecules still exists. In this contribution, we develop a new technique for sensing carcinoembryonic antigen (CEA), one of the important cancer biomarkers, usi...