Amino Nitrogen Quantum Dots-Based Nanoprobe for Fluorescence Detection and Imaging of Cysteine in Biological Samples

• Published in: Analytical chemistry (Washington) Vol. 89; no. 7; pp. 4238 - 4245
• Main Authors: Tang, Zhijiao, Lin, Zhenhua, Li, Gongke, Hu, Yuling
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 04.04.2017
• Subjects: Adenocarcinoma of Lung - blood; Adenocarcinoma of Lung - pathology; Ammonia; Biosensing Techniques; Cell Line, Tumor; Cell Survival; Cysteine; Cysteine - blood; Fluorescence; Fluorescent Dyes - chemical synthesis; Fluorescent Dyes - chemistry; Gold; Humans; Imaging; Lung Neoplasms - blood; Lung Neoplasms - pathology; Nanoparticles; Nanoparticles - chemistry; Nanostructure; Nitrogen; Nitrogen - chemistry; Particle Size; Permeability; Quantum dots; Quantum Dots - chemistry; Spectrometry, Fluorescence; Surface Properties

Fluorescent amino nitrogen quantum dots (aN-dots) were synthesized by microwave-assisted method using 2-azidoimidazole and aqueous ammonia. The aN-dots have a nitrogen component up to 40%, which exhibit high fluorescence quantum yield, good photostability, and excellent biocompatibility. We further...