Tumor-Marker-Mediated “on-Demand” Drug Release and Real-Time Monitoring System Based on Multifunctional Mesoporous Silica Nanoparticles

• Published in: Analytical chemistry (Washington) Vol. 86; no. 20; pp. 10239 - 10245
• Main Authors: Li, Xiang-Ling, Hao, Nan, Chen, Hong-Yuan, Xu, Jing-Juan
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 21.10.2014
• Subjects: antineoplastic agents; Biomarkers, Tumor - chemistry; Biomarkers, Tumor - metabolism; Cell Line, Tumor; Cells; Delayed-Action Preparations; Drug delivery systems; drug toxicity; Drugs; Energy transfer; fluorescein; Fluorescence; Fretting; Humans; messenger RNA; Monitoring; Nanoparticles; Nanoparticles - chemistry; Oligonucleotides; Porosity; porous media; pro-apoptotic proteins; Real time; Ribonucleic acid; RNA; Silica; Silicon Dioxide - chemistry; Strands; Toxicity

“On-demand” drug release can maximize therapeutic efficacy for specific states of malignancies and minimize drug toxicity to healthy cells. Meanwhile, there is lack of a real-time monitoring platform to accurately investigate the amount of anticancer drugs released, especially nonfluorescent ones. S...