Various pfcrt and pfmdr1 Genotypes of Plasmodium falciparum Cocirculate with P. malariae, P. ovale spp., and P. vivax in Northern Angola

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Published inAntimicrobial Agents and Chemotherapy Vol. 56; no. 10; pp. 5271 - 5277
Main Authors FANCONY, Cláudia, GAMBOA, Dina, SEBASTIAO, Yuri, HALLETT, Rachel, SUTHERLAND, Colin, SOUSA-FIGUEIREDO, José Carlos, VAZ NERY, Susana
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.10.2012
Subjects
Africa
Angola
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimalarials - therapeutic use
Biological and medical sciences
Chloroquine - therapeutic use
Epidemiology and Surveillance
Genotype
Humans
Malaria, Falciparum - drug therapy
Malaria, Falciparum - parasitology
Medical sciences
Pharmacology. Drug treatments
Plasmodium falciparum
Plasmodium falciparum - drug effects
Plasmodium falciparum - genetics
Plasmodium falciparum - pathogenicity
Plasmodium vivax
Plasmodium vivax - drug effects
Plasmodium vivax - genetics
Plasmodium vivax - pathogenicity
Protozoan Proteins
Protozoan Proteins - genetics
Angola
Africa
Protozoa
Plasmodium falciparum
Genotype
Apicomplexa
Typing
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AbstractList Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
Artemisinin-based combination therapy for malaria has become widely available across Africa. Populations of Plasmodium falciparum that were previously dominated by chloroquine (CQ)-resistant genotypes are now under different drug selection pressures. P. malariae , P. ovale curtisi , and P. ovale wallikeri are sympatric with P. falciparum across the continent and are frequently present as coinfections. The prevalence of human Plasmodium species was determined by PCR using DNA from blood spots collected during a cross-sectional survey in northern Angola. P. falciparum was genotyped at resistance-associated loci in pfcrt and pfmdr1 by real-time PCR or by direct sequencing of amplicons. Of the 3,316 samples collected, 541 (16.3%) contained Plasmodium species infections; 477 (88.2%) of these were P. falciparum alone, 6.5% were P. falciparum and P. malariae together, and 1.1% were P. vivax alone. The majority of the remainder (3.7%) harbored P. ovale curtisi or P. ovale wallikeri alone or in combination with other species. Of 430 P. falciparum isolates genotyped for pfcrt , 61.6% carried the wild-type allele CVMNK at codons 72 to 76, either alone or in combination with the resistant allele CVIET. No other pfcrt allele was found. Wild-type alleles dominated at codons 86, 184, 1034, 1042, and 1246 of the pfmdr1 locus among the sequenced isolates. In contrast to previous studies, P. falciparum in the study area comprises an approximately equal mix of genotypes associated with CQ sensitivity and with CQ resistance, suggesting either lower drug pressure due to poor access to treatment in rural areas or a rapid impact of the policy change away from the use of standard monotherapies.
Artemisinin-based combination therapy for malaria has become widely available across Africa. Populations of Plasmodium falciparum that were previously dominated by chloroquine (CQ)-resistant genotypes are now under different drug selection pressures. P. malariae, P. ovale curtisi, and P. ovale wallikeri are sympatric with P. falciparum across the continent and are frequently present as coinfections. The prevalence of human Plasmodium species was determined by PCR using DNA from blood spots collected during a cross-sectional survey in northern Angola. P. falciparum was genotyped at resistance-associated loci in pfcrt and pfmdr1 by real-time PCR or by direct sequencing of amplicons. Of the 3,316 samples collected, 541 (16.3%) contained Plasmodium species infections; 477 (88.2%) of these were P. falciparum alone, 6.5% were P. falciparum and P. malariae together, and 1.1% were P. vivax alone. The majority of the remainder (3.7%) harbored P. ovale curtisi or P. ovale wallikeri alone or in combination with other species. Of 430 P. falciparum isolates genotyped for pfcrt, 61.6% carried the wild-type allele CVMNK at codons 72 to 76, either alone or in combination with the resistant allele CVIET. No other pfcrt allele was found. Wild-type alleles dominated at codons 86, 184, 1034, 1042, and 1246 of the pfmdr1 locus among the sequenced isolates. In contrast to previous studies, P. falciparum in the study area comprises an approximately equal mix of genotypes associated with CQ sensitivity and with CQ resistance, suggesting either lower drug pressure due to poor access to treatment in rural areas or a rapid impact of the policy change away from the use of standard monotherapies.
Author Rachel Hallett
Cláudia Fançony
Susana Vaz Nery
Yuri Sebastião
Colin Sutherland
José Carlos Sousa-Figueiredo
Dina Gamboa
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  surname: SUTHERLAND
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  surname: VAZ NERY
  fullname: VAZ NERY, Susana
  organization: CISA Project-Health Research Centre in Angola, Caxito, Angola
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Artemisinin-based combination therapy for malaria has become widely available across Africa. Populations of Plasmodium falciparum that were previously...
Artemisinin-based combination therapy for malaria has become widely available across Africa. Populations of Plasmodium falciparum that were previously...
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StartPage 5271
SubjectTerms Africa
Angola
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimalarials - therapeutic use
Biological and medical sciences
Chloroquine - therapeutic use
Epidemiology and Surveillance
Genotype
Humans
Malaria, Falciparum - drug therapy
Malaria, Falciparum - parasitology
Medical sciences
Pharmacology. Drug treatments
Plasmodium falciparum
Plasmodium falciparum - drug effects
Plasmodium falciparum - genetics
Plasmodium falciparum - pathogenicity
Plasmodium vivax
Plasmodium vivax - drug effects
Plasmodium vivax - genetics
Plasmodium vivax - pathogenicity
Protozoan Proteins
Protozoan Proteins - genetics
Title Various pfcrt and pfmdr1 Genotypes of Plasmodium falciparum Cocirculate with P. malariae, P. ovale spp., and P. vivax in Northern Angola
URI http://aac.asm.org/content/56/10/5271.abstract
https://www.ncbi.nlm.nih.gov/pubmed/22850519
https://journals.asm.org/doi/10.1128/AAC.00559-12
https://search.proquest.com/docview/1039881336
https://pubmed.ncbi.nlm.nih.gov/PMC3457352
Volume 56
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