Synthesis of Silver Nanoparticles Using Curcumin-Cyclodextrins Loaded into Bacterial Cellulose-Based Hydrogels for Wound Dressing Applications
Chronic wounds are often recalcitrant to treatment because of high microbial bioburden and the problem of microbial resistance. Silver is a broad-spectrum natural antimicrobial agent with wide applications extending to proprietary wound dressings. Recently, silver nanoparticles have attracted attent...
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| Published in | Biomacromolecules Vol. 21; no. 5; pp. 1802 - 1811 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Chemical Society
11.05.2020
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Chronic wounds are often recalcitrant to treatment because of high microbial bioburden and the problem of microbial resistance. Silver is a broad-spectrum natural antimicrobial agent with wide applications extending to proprietary wound dressings. Recently, silver nanoparticles have attracted attention in wound management. In the current study, the green synthesis of nanoparticles was accomplished using a natural reducing agent, curcumin, which is a natural polyphenolic compound that is well-known as a wound-healing agent. The hydrophobicity of curcumin was overcome by its microencapsulation in cyclodextrins. This study demonstrates the production, characterization of silver nanoparticles using aqueous curcumin:hydroxypropyl-β-cyclodextrin complex and loading them into bacterial cellulose hydrogel with moist wound-healing properties. These silver nanoparticle-loaded bacterial cellulose hydrogels were characterized for wound-management applications. In addition to high cytocompatibility, these novel dressings exhibited antimicrobial activity against three common wound-infecting pathogenic microbes Staphylococcus aureus, Pseudomonas aeruginosa, and Candida auris. |
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| AbstractList | Chronic wounds are often recalcitrant to treatment because of high microbial bioburden and the problem of microbial resistance. Silver is a broad-spectrum natural antimicrobial agent with wide applications extending to proprietary wound dressings. Recently, silver nanoparticles have attracted attention in wound management. In the current study, the green synthesis of nanoparticles was accomplished using a natural reducing agent, curcumin, which is a natural polyphenolic compound that is well-known as a wound-healing agent. The hydrophobicity of curcumin was overcome by its microencapsulation in cyclodextrins. This study demonstrates the production, characterization of silver nanoparticles using aqueous curcumin:hydroxypropyl-β-cyclodextrin complex and loading them into bacterial cellulose hydrogel with moist wound-healing properties. These silver nanoparticle-loaded bacterial cellulose hydrogels were characterized for wound-management applications. In addition to high cytocompatibility, these novel dressings exhibited antimicrobial activity against three common wound-infecting pathogenic microbes
,
, and
. Chronic wounds are often recalcitrant to treatment because of high microbial bioburden and the problem of microbial resistance. Silver is a broad-spectrum natural antimicrobial agent with wide applications extending to proprietary wound dressings. Recently, silver nanoparticles have attracted attention in wound management. In the current study, the green synthesis of nanoparticles was accomplished using a natural reducing agent, curcumin, which is a natural polyphenolic compound that is well-known as a wound-healing agent. The hydrophobicity of curcumin was overcome by its microencapsulation in cyclodextrins. This study demonstrates the production, characterization of silver nanoparticles using aqueous curcumin:hydroxypropyl-β-cyclodextrin complex and loading them into bacterial cellulose hydrogel with moist wound-healing properties. These silver nanoparticle-loaded bacterial cellulose hydrogels were characterized for wound-management applications. In addition to high cytocompatibility, these novel dressings exhibited antimicrobial activity against three common wound-infecting pathogenic microbes Staphylococcus aureus, Pseudomonas aeruginosa, and Candida auris.Chronic wounds are often recalcitrant to treatment because of high microbial bioburden and the problem of microbial resistance. Silver is a broad-spectrum natural antimicrobial agent with wide applications extending to proprietary wound dressings. Recently, silver nanoparticles have attracted attention in wound management. In the current study, the green synthesis of nanoparticles was accomplished using a natural reducing agent, curcumin, which is a natural polyphenolic compound that is well-known as a wound-healing agent. The hydrophobicity of curcumin was overcome by its microencapsulation in cyclodextrins. This study demonstrates the production, characterization of silver nanoparticles using aqueous curcumin:hydroxypropyl-β-cyclodextrin complex and loading them into bacterial cellulose hydrogel with moist wound-healing properties. These silver nanoparticle-loaded bacterial cellulose hydrogels were characterized for wound-management applications. In addition to high cytocompatibility, these novel dressings exhibited antimicrobial activity against three common wound-infecting pathogenic microbes Staphylococcus aureus, Pseudomonas aeruginosa, and Candida auris. Chronic wounds are often recalcitrant to treatment because of high microbial bioburden and the problem of microbial resistance. Silver is a broad-spectrum natural antimicrobial agent with wide applications extending to proprietary wound dressings. Recently, silver nanoparticles have attracted attention in wound management. In the current study, the green synthesis of nanoparticles was accomplished using a natural reducing agent, curcumin, which is a natural polyphenolic compound that is well-known as a wound-healing agent. The hydrophobicity of curcumin was overcome by its microencapsulation in cyclodextrins. This study demonstrates the production, characterization of silver nanoparticles using aqueous curcumin:hydroxypropyl-β-cyclodextrin complex and loading them into bacterial cellulose hydrogel with moist wound-healing properties. These silver nanoparticle-loaded bacterial cellulose hydrogels were characterized for wound-management applications. In addition to high cytocompatibility, these novel dressings exhibited antimicrobial activity against three common wound-infecting pathogenic microbes Staphylococcus aureus, Pseudomonas aeruginosa, and Candida auris. Chronic wounds are often recalcitrant to treatment because of high microbial bioburden and the problem of microbial resistance. Silver is a broad-spectrum natural antimicrobial agent with wide applications extending to proprietary wound dressings. Recently, silver nanoparticles have attracted attention in wound management. In the current study, the green synthesis of nanoparticles was accomplished using a natural reducing agent, curcumin, which is a natural polyphenolic compound that is well-known as a wound-healing agent. The hydrophobicity of curcumin was overcome by its microencapsulation in cyclodextrins. This study demonstrates the production, characterization of silver nanoparticles using aqueous curcumin:hydroxypropyl-β-cyclodextrin complex and loading them into bacterial cellulose hydrogel with moist wound-healing properties. These silver nanoparticle-loaded bacterial cellulose hydrogels were characterized for wound-management applications. In addition to high cytocompatibility, these novel dressings exhibited antimicrobial activity against three common wound-infecting pathogenic microbes Staphylococcus aureus , Pseudomonas aeruginosa , and Candida auris . |
| Author | Briffa, Sophie M Gupta, Abhishek Adamus, Grazyna Kannappan, Vinodh Kowalczuk, Marek Swingler, Sam Radecka, Iza Martin, Claire Gibson, Hazel |
| AuthorAffiliation | Research Institute in Healthcare Science, Faculty of Science and Engineering Wolverhampton School of Sciences, Faculty of Science and Engineering Centre of Polymer and Carbon Materials Department of Biological Sciences, School of Sciences and the Environment School of Pharmacy, Faculty of Science and Engineering School of Geography, Earth and Environmental Sciences |
| AuthorAffiliation_xml | – name: Research Institute in Healthcare Science, Faculty of Science and Engineering – name: School of Pharmacy, Faculty of Science and Engineering – name: School of Geography, Earth and Environmental Sciences – name: Department of Biological Sciences, School of Sciences and the Environment – name: Wolverhampton School of Sciences, Faculty of Science and Engineering – name: Centre of Polymer and Carbon Materials |
| Author_xml | – sequence: 1 givenname: Abhishek orcidid: 0000-0001-7901-1818 surname: Gupta fullname: Gupta, Abhishek email: a.gupta@wlv.ac.uk organization: Research Institute in Healthcare Science, Faculty of Science and Engineering – sequence: 2 givenname: Sophie M surname: Briffa fullname: Briffa, Sophie M organization: School of Geography, Earth and Environmental Sciences – sequence: 3 givenname: Sam surname: Swingler fullname: Swingler, Sam organization: Wolverhampton School of Sciences, Faculty of Science and Engineering – sequence: 4 givenname: Hazel surname: Gibson fullname: Gibson, Hazel organization: Research Institute in Healthcare Science, Faculty of Science and Engineering – sequence: 5 givenname: Vinodh surname: Kannappan fullname: Kannappan, Vinodh organization: Research Institute in Healthcare Science, Faculty of Science and Engineering – sequence: 6 givenname: Grazyna surname: Adamus fullname: Adamus, Grazyna organization: Centre of Polymer and Carbon Materials – sequence: 7 givenname: Marek orcidid: 0000-0002-2877-7466 surname: Kowalczuk fullname: Kowalczuk, Marek email: marek.kowalczuk@cmpw-pan.edu.pl organization: Centre of Polymer and Carbon Materials – sequence: 8 givenname: Claire orcidid: 0000-0002-5497-4594 surname: Martin fullname: Martin, Claire organization: Department of Biological Sciences, School of Sciences and the Environment – sequence: 9 givenname: Iza orcidid: 0000-0003-3257-8803 surname: Radecka fullname: Radecka, Iza email: I.Radecka@wlv.ac.uk organization: Research Institute in Healthcare Science, Faculty of Science and Engineering |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31967794$$D View this record in MEDLINE/PubMed |
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| Copyright | 2020 American Chemical Society |
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| Snippet | Chronic wounds are often recalcitrant to treatment because of high microbial bioburden and the problem of microbial resistance. Silver is a broad-spectrum... Chronic wounds are often recalcitrant to treatment because of high microbial bioburden and the problem of microbial resistance. Silver is a broad-spectrum... |
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| SubjectTerms | anti-infective agents antimicrobial properties Candida cellulose curcumin cyclodextrins hydrogels hydrophobicity microbial load microencapsulation nanosilver Pseudomonas aeruginosa silver Staphylococcus aureus wound treatment |
| Title | Synthesis of Silver Nanoparticles Using Curcumin-Cyclodextrins Loaded into Bacterial Cellulose-Based Hydrogels for Wound Dressing Applications |
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