MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants

• Published in: Antimicrobial Agents and Chemotherapy Vol. 56; no. 8; pp. 4161 - 4167
• Main Authors: Summa, Vincenzo, Ludmerer, Steven W., McCauley, John A., Fandozzi, Christine, Burlein, Christine, Claudio, Giuliano, Coleman, Paul J., DiMuzio, Jillian M., Ferrara, Marco, Di Filippo, Marcello, Gates, Adam T., Graham, Donald J., Harper, Steven, Hazuda, Daria J., McHale, Carolyn, Monteagudo, Edith, Pucci, Vincenzo, Rowley, Michael, Rudd, Michael T., Soriano, Aileen, Stahlhut, Mark W., Vacca, Joseph P., Olsen, David B., Liverton, Nigel J., Carroll, Steven S.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.08.2012
• Subjects: Amides; Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral Agents; Antiviral Agents - pharmacology; Biological and medical sciences; Carbamates; Cyclopropanes; Dogs; Drug Resistance, Viral; Genotype; Hepacivirus; Hepacivirus - drug effects; Hepacivirus - enzymology; Hepacivirus - genetics; Hepatitis C, Chronic - drug therapy; Hepatitis C, Chronic - virology; Liver - drug effects; Medical sciences; Pan troglodytes; Pharmacology. Drug treatments; Protease Inhibitors; Protease Inhibitors - pharmacology; Quinoxalines; Quinoxalines - metabolism; Quinoxalines - pharmacokinetics; Quinoxalines - pharmacology; Rats; Sulfonamides; Viral Load - drug effects; Viral Nonstructural Proteins; Viral Nonstructural Proteins - antagonists & inhibitors; Rat; Monkey; Pharmacotherapy; Hepatic disease; Primates; Dog; Viral hepatitis C; Drug; Fissipedia; Carnivora; Treatment resistance; Enzyme; Rodentia; Genotype; Infection; Virus; Peptidases; Vertebrata; Mammalia; Treatment; Viral disease; Animal; Hydrolases; Digestive diseases; Flaviviridae; Hepatitis C virus; Hepacivirus; Protease inhibitor

Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commerc...