MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants - Summa, Vincenzo; Ludmerer, Steven W.; McCauley, John A.; Fandozzi, Christine; Burlein, Christine; Claudio, Giuliano; Coleman, Paul J.; DiMuzio, Jillian M.; Ferrara, Marco; Di Filippo, Marcello; Gates, Adam T.; Graham, Donald J.; et al. (Antimicrobial Agents and Chemotherapy, 2012)
Keywords: Amides; Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral Agents; Antiviral Agents - pharmacology; Biological and medical sciences; Carbamates; Cyclopropanes; Dogs; Drug Resistance, Viral; Genotype; Hepacivirus; Hepacivirus - drug effects; Hepacivirus - enzymology; Hepacivirus - genetics; Hepatitis C, Chronic - drug therapy; Hepatitis C, Chronic - virology; Liver - drug effects; Medical sciences; Pan troglodytes; Pharmacology. Drug treatments; Protease Inhibitors; Protease Inhibitors - pharmacology; Quinoxalines; Quinoxalines - metabolism; Quinoxalines - pharmacokinetics; Quinoxalines - pharmacology; Rats; Sulfonamides; Viral Load - drug effects; Viral Nonstructural Proteins; Viral Nonstructural Proteins - antagonists & inhibitors; Rat; Monkey; Pharmacotherapy; Hepatic disease; Primates; Dog; Viral hepatitis C; Drug; Fissipedia; Carnivora; Treatment resistance; Enzyme; Rodentia; Genotype; Infection; Virus; Peptidases; Vertebrata; Mammalia; Treatment; Viral disease; Animal; Hydrolases; Digestive diseases; Flaviviridae; Hepatitis C virus; Hepacivirus; Protease inhibitor