Single- and Multiple-Ascending-Dose Studies of the NS3 Protease Inhibitor Asunaprevir in Subjects with or without Chronic Hepatitis C - Pasquinelli, Claudio; McPhee, Fiona; Eley, Timothy; Villegas, Criselda; Sandy, Katrina; Sheridan, Pamela; Persson, Anna; Huang, Shu-Pang; Hernandez, Dennis; Sheaffer, Amy K.; Scola, Paul; Marbury, Thomas; et al. (Antimicrobial Agents and Chemotherapy, 2012)
Keywords: Adult; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral Agents; Biological and medical sciences; Dose-Response Relationship, Drug; Double-Blind Method; Drug Resistance, Viral; Electrocardiography - drug effects; Female; Hepacivirus; Hepacivirus - drug effects; Hepacivirus - genetics; Hepatitis C, Chronic; Hepatitis C, Chronic - drug therapy; Hepatitis C, Chronic - virology; Human viral diseases; Humans; Infectious diseases; Isoquinolines; Isoquinolines - administration & dosage; Isoquinolines - adverse effects; Isoquinolines - therapeutic use; Male; Medical sciences; Pharmacology. Drug treatments; Replicon; RNA, Viral - drug effects; Sample Size; Sulfonamides; Sulfonamides - administration & dosage; Sulfonamides - adverse effects; Sulfonamides - therapeutic use; Viral diseases; Viral hepatitis; Viral Nonstructural Proteins; Viral Nonstructural Proteins - antagonists & inhibitors; Infection; Multiple dose; Human; Viral disease; Digestive diseases; Hepatic disease; Antiviral; Protease inhibitor; Viral hepatitis C