Normalizing and Integrating Metabolomics Data

• Published in: Analytical chemistry (Washington) Vol. 84; no. 24; pp. 10768 - 10776
• Main Authors: De Livera, Alysha M, Dias, Daniel A, De Souza, David, Rupasinghe, Thusitha, Pyke, James, Tull, Dedreia, Roessner, Ute, McConville, Malcolm, Speed, Terence P
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 18.12.2012
• Subjects: Analytical chemistry; Biological variation; chemical analysis; Chemistry; data analysis; Databases, Factual - statistics & numerical data; Exact sciences and technology; Information; Integration; Metabolites; metabolomics; Metabolomics - methods; Systems Integration; Performance evaluation; Metabolomics; Metabolite; Sample; Use; Identification; Laboratory; Method; Application

Metabolomics research often requires the use of multiple analytical platforms, batches of samples, and laboratories, any of which can introduce a component of unwanted variation. In addition, every experiment is subject to within-platform and other experimental variation, which often includes unwant...