Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator

• Published in: ACS medicinal chemistry letters Vol. 4; no. 3; pp. 333 - 337
• Main Authors: Pan, Shifeng, Gray, Nathanael S., Gao, Wenqi, Mi, Yuan, Fan, Yi, Wang, Xing, Tuntland, Tove, Che, Jianwei, Lefebvre, Sophie, Chen, Yu, Chu, Alan, Hinterding, Klaus, Gardin, Anne, End, Peter, Heining, Peter, Bruns, Christian, Cooke, Nigel G., Nuesslein-Hildesheim, Barbara
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 14.03.2013; Amer Chemical Soc
• Subjects: Chemistry, Medicinal; Letter; Life Sciences & Biomedicine; Pharmacology & Pharmacy; Science & Technology; S1P1 agonist; S1P receptor; lymphocytes; S1P agonist; AGONISTS; SPHINGOSINE-1-PHOSPHATE; INSIGHTS

A novel series of alkoxyimino derivatives as S1P1 agonists were discovered through de novo design using FTY720 as the chemical starting point. Extensive structure–activity relationship studies led to the discovery of (E)-1-(4-(1-(((4-cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzy...