Anterior thalamic nuclei, but not retrosplenial cortex, lesions abolish latent inhibition in rats

• Published in: Behavioral neuroscience Vol. 132; no. 5; p. 378
• Main Authors: Nelson, Andrew J D, Powell, Anna L, Kinnavane, Lisa, Aggleton, John P
• Format: Journal Article
• Language: English
• Published: United States 01.10.2018
• Subjects: Animals; Anterior Thalamic Nuclei - drug effects; Anterior Thalamic Nuclei - physiopathology; Auditory Perception - physiology; Cerebral Cortex - drug effects; Cerebral Cortex - physiopathology; Conditioning (Psychology) - physiology; Ibotenic Acid; Inhibition (Psychology); Male; Maze Learning - physiology; Motor Activity - physiology; N-Methylaspartate; Neurotoxins; Random Allocation; Rats

The present study examined the effects of excitotoxic lesions in 2 closely related structures, the anterior thalamic nuclei and the retrosplenial cortex, on latent inhibition. Latent inhibition occurs when nonreinforced preexposure to a stimulus retards the subsequent acquisition of conditioned resp...