Association of Intravenous Immunoglobulins Plus Methylprednisolone vs Immunoglobulins Alone With Course of Fever in Multisystem Inflammatory Syndrome in Children

• Published in: JAMA : the journal of the American Medical Association Vol. 325; no. 9; pp. 855 - 864
• Main Authors: Ouldali, Naïm, Toubiana, Julie, Antona, Denise, Javouhey, Etienne, Madhi, Fouad, Lorrot, Mathie, Léger, Pierre-Louis, Galeotti, Caroline, Claude, Caroline, Wiedemann, Arnaud, Lachaume, Noémie, Ovaert, Caroline, Dumortier, Morgane, Kahn, Jean-Emmanuel, Mandelcwajg, Alexis, Percheron, Lucas, Biot, Blandine, Bordet, Jeanne, Girardin, Marie-Laure, Yang, David Dawei, Grimaud, Marion, Oualha, Mehdi, Allali, Slimane, Bajolle, Fanny, Beyler, Constance, Meinzer, Ulrich, Levy, Michael, Paulet, Ana-Maria, Levy, Corinne, Cohen, Robert, Belot, Alexandre, Angoulvant, François
• Format: Journal Article
• Language: English
• Published: United States American Medical Association 02.03.2021; American Medical Association (AMA)
• Subjects: Adolescent; Child; Child, Preschool; Children; Combined Modality Therapy; Coronaviruses; COVID-19; COVID-19 - complications; COVID-19 - drug therapy; COVID-19 - therapy; COVID-19 Drug Treatment; Female; Fever; Fever - etiology; France; Glucocorticoids; Glucocorticoids - adverse effects; Glucocorticoids - therapeutic use; Health services; Heart; Hemodynamics; Humans; Immunoglobulins; Immunoglobulins, Intravenous; Immunoglobulins, Intravenous - therapeutic use; Inflammation; Intensive care; Intensive Care Units, Pediatric; Intravenous administration; Length of Stay; Life Sciences; Male; Methylprednisolone; Methylprednisolone - adverse effects; Methylprednisolone - therapeutic use; Multisystem inflammatory syndrome in children; Online First; Original Investigation; Pediatrics; Propensity Score; Public health; Recurrence; Respiratory diseases; Retrospective Studies; Risk; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Systemic Inflammatory Response Syndrome; Systemic Inflammatory Response Syndrome - complications; Systemic Inflammatory Response Syndrome - drug therapy; Systemic Inflammatory Response Syndrome - therapy; Therapy; Treatment Outcome; Ventricle; Viral diseases; France

IMPORTANCE: Multisystem inflammatory syndrome in children (MIS-C) is the most severe pediatric disease associated with severe acute respiratory syndrome coronavirus 2 infection, potentially life-threatening, but the optimal therapeutic strategy remains unknown. OBJECTIVE: To compare intravenous immu...