Neuroprotective Effects of Resveratrol on Cerebral Ischemia-Induced Neuron Loss Mediated by Free Radical Scavenging and Cerebral Blood Flow Elevation
Resveratrol is a natural phytoestrogen and possesses many biological functions such as anti-inflammatory activity and protection against atherosclerosis and myocardial infraction. The present study was carried out to elucidate the neuroprotective effect and possible mechanism of resveratrol on cereb...
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Published in | Journal of agricultural and food chemistry Vol. 54; no. 8; pp. 3126 - 3131 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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Washington, DC
American Chemical Society
19.04.2006
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Abstract | Resveratrol is a natural phytoestrogen and possesses many biological functions such as anti-inflammatory activity and protection against atherosclerosis and myocardial infraction. The present study was carried out to elucidate the neuroprotective effect and possible mechanism of resveratrol on cerebral ischemia-induced hippocampus neuron loss. Sixty adult male rats underwent general anesthesia (urethane, 1.4 g/kg, i.p.) and were divided into three groups: sham operation, ischemia treatment, and ischemia combined with resveratrol administration (20 mg/kg, i.v.). The carotid artery was bilaterally ligated to induce cerebral ischemia. Microdialysis and high-performance liquid chromatography were used to analyze dihydroxybenzoic acid (DHBA) that reflected the hippocampal hydroxyl radical level. Hippocampal nitric oxide was assayed among different groups. During cerebral ischemia, the hydroxyl radical levels were elevated in rats and animals displayed severe neuronal loss. A single dose of resveratrol significantly increased the nitric oxide level and decreased the hydroxyl radical level. The reduction of cerebral blood flow and neuronal loss were also attenuated by resveratrol treatment. The results demonstrated that a single infusion of resveratrol could elicit neuroprotective effects on cerebral ischemia-induced neuron damage through free radical scavenging and cerebral blood elevation due to NO release. Keywords: Phytoestrogen; ischemia; free radicals; nitric oxide; neuronal damage |
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AbstractList | Resveratrol is a natural phytoestrogen and possesses many biological functions such as anti-inflammatory activity and protection against atherosclerosis and myocardial infraction. The present study was carried out to elucidate the neuroprotective effect and possible mechanism of resveratrol on cerebral ischemia-induced hippocampus neuron loss. Sixty adult male rats underwent general anesthesia (urethane, 1.4 g/kg, i.p.) and were divided into three groups: sham operation, ischemia treatment, and ischemia combined with resveratrol administration (20 mg/kg, i.v.). The carotid artery was bilaterally ligated to induce cerebral ischemia. Microdialysis and high-performance liquid chromatography were used to analyze dihydroxybenzoic acid (DHBA) that reflected the hippocampal hydroxyl radical level. Hippocampal nitric oxide was assayed among different groups. During cerebral ischemia, the hydroxyl radical levels were elevated in rats and animals displayed severe neuronal loss. A single dose of resveratrol significantly increased the nitric oxide level and decreased the hydroxyl radical level. The reduction of cerebral blood flow and neuronal loss were also attenuated by resveratrol treatment. The results demonstrated that a single infusion of resveratrol could elicit neuroprotective effects on cerebral ischemia-induced neuron damage through free radical scavenging and cerebral blood elevation due to NO release. Resveratrol is a natural phytoestrogen and possesses many biological functions such as anti-inflammatory activity and protection against atherosclerosis and myocardial infraction. The present study was carried out to elucidate the neuroprotective effect and possible mechanism of resveratrol on cerebral ischemia-induced hippocampus neuron loss. Sixty adult male rats underwent general anesthesia (urethane, 1.4 g/kg, i.p.) and were divided into three groups: sham operation, ischemia treatment, and ischemia combined with resveratrol administration (20 mg/kg, i.v.). The carotid artery was bilaterally ligated to induce cerebral ischemia. Microdialysis and high-performance liquid chromatography were used to analyze dihydroxybenzoic acid (DHBA) that reflected the hippocampal hydroxyl radical level. Hippocampal nitric oxide was assayed among different groups. During cerebral ischemia, the hydroxyl radical levels were elevated in rats and animals displayed severe neuronal loss. A single dose of resveratrol significantly increased the nitric oxide level and decreased the hydroxyl radical level. The reduction of cerebral blood flow and neuronal loss were also attenuated by resveratrol treatment. The results demonstrated that a single infusion of resveratrol could elicit neuroprotective effects on cerebral ischemia-induced neuron damage through free radical scavenging and cerebral blood elevation due to NO release. Keywords: Phytoestrogen; ischemia; free radicals; nitric oxide; neuronal damage |
Author | Yang, Yi Ling Lu, Kwok Tung Chiou, Robin Y. Y Chen, Ming Hsiang Tseng, Wan Ting Chen, Li Ging Hsieh, Hsiang Tsang |
Author_xml | – sequence: 1 givenname: Kwok Tung surname: Lu fullname: Lu, Kwok Tung – sequence: 2 givenname: Robin Y. Y surname: Chiou fullname: Chiou, Robin Y. Y – sequence: 3 givenname: Li Ging surname: Chen fullname: Chen, Li Ging – sequence: 4 givenname: Ming Hsiang surname: Chen fullname: Chen, Ming Hsiang – sequence: 5 givenname: Wan Ting surname: Tseng fullname: Tseng, Wan Ting – sequence: 6 givenname: Hsiang Tsang surname: Hsieh fullname: Hsieh, Hsiang Tsang – sequence: 7 givenname: Yi Ling surname: Yang fullname: Yang, Yi Ling |
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Keywords | Phytoestrogen neuronal damage free radicals Nitric oxide Resveratrol Damage Free radical Blood ischemia |
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SubjectTerms | Animals antioxidant activity Biological and medical sciences blood flow Blood Pressure - drug effects Brain Ischemia - drug therapy Brain Ischemia - pathology Brain Ischemia - physiopathology central nervous system diseases cerebrum Food industries Free Radical Scavengers free radicals Fundamental and applied biological sciences. Psychology Heart Rate - drug effects hippocampus Hippocampus - blood supply Hippocampus - chemistry hydroxyl radicals intravenous injection ischemia Male neurons Neurons - pathology Neuroprotective Agents - therapeutic use neuroprotective effect nitric oxide Rats Rats, Wistar resveratrol Stilbenes - therapeutic use Superoxide Dismutase vasodilation |
Title | Neuroprotective Effects of Resveratrol on Cerebral Ischemia-Induced Neuron Loss Mediated by Free Radical Scavenging and Cerebral Blood Flow Elevation |
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