The rostral medial frontal cortex is crucial for engagement in consummatory behavior

• Published in: Behavioral neuroscience Vol. 136; no. 6; p. 551
• Main Authors: White, Samantha R, Laubach, Mark
• Format: Journal Article
• Language: English
• Published: United States 01.12.2022
• Subjects: Animals; Consummatory Behavior; Enkephalin, Ala-MePhe-Gly- - metabolism; Enkephalin, Ala-MePhe-Gly- - pharmacology; Frontal Lobe - physiology; Male; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu - metabolism; Sucrose
• ISSN: 1939-0084
• DOI: 10.1037/bne0000523

The medial frontal cortex (MFC) in rodents emits rhythmic activity that is entrained to the animal's licking cycle during consumption and encodes the value of consumed fluids. These signals are especially prominent in the rostral half of the MFC. This region is located above an orbitofrontal region where mu-opioid receptors regulate intake and reversible inactivation reduces behavioral measures associated with the incentive value and palatability of liquid sucrose. Here, we examined the effects of reversible inactivation and stimulation of mu-opioid receptors in rostral MFC on behavior in an incentive contrast licking task. Adult male rats licked to receive access to liquid sucrose, which alternated between high (16%) and low (4%) values over 30 s periods. Bilateral infusion of muscimol reduced the total number of licks over the 30 min test sessions, the time spent actively consuming sucrose, and the ratio of licks for the higher and lower value fluids. Inactivation did not alter licking frequency or variability or microstructural measures such as the duration of licking bouts that are classically associated with the palatability of a liquid reward. Infusions of [d-Ala2, -Me-Phe4, Gly5-ol]-enkephalin (DAMGO; 1 μg/μL) at the same sites had inconsistent behavioral effects across different subjects. Our findings suggest that the rostral MFC has a distinct role in the control of consummatory behavior and contributes to persistent consumption and not to the expression of palatability. (PsycInfo Database Record (c) 2022 APA, all rights reserved).