Efficacy of dicloxacillin-coated polyurethane catheters in preventing subcutaneous Staphylococcus aureus infection in mice

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Published inAntimicrobial Agents and Chemotherapy Vol. 33; no. 8; pp. 1174 - 1178
Main Authors SHERERTZ, R. J, FORMAN, D. M, SOLOMON, D. D
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.08.1989
Subjects
Animals
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Catheterization
Dicloxacillin
Dicloxacillin - analysis
Dicloxacillin - therapeutic use
Half-Life
Medical sciences
Mice
Mice, Inbred ICR
Pharmacology. Drug treatments
Research Article
Skin Diseases, Infectious
Skin Diseases, Infectious - prevention & control
Staphylococcal Infections
Staphylococcal Infections - microbiology
Staphylococcal Infections - prevention & control
Time Factors
Rodentia
Catheter
Embedding
Infection
Prevention
In vivo
Vertebrata
Antibiotic
Chemotherapy
Experimental disease
Mammalia
Treatment
Mouse
Animal
Bacteriosis
Bacteria
Micrococcales
Subcutaneous administration
Micrococcaceae
Staphylococcus aureus
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AbstractList In a mouse model, dicloxacillin-coated polyurethane catheters or control (uncoated) catheters were placed subcutaneously and then Staphylococcus aureus was inoculated at the time of insertion, 24 or 48 h later. The in vivo half-life of the antibiotic was 11 to 16 h. When 10(5) CFU of S. aureus were inoculated at the time of catheter insertion, dicloxacillin-coated catheters kept the number of S. aureus removed from catheters by sonication below 10(2) CFU at 12, 24, 48, and 96 h after inoculation compared with titers greater than 10(3.5) CFU for control catheters (P less than 0.05). When S. aureus was inoculated 24 h after catheter insertion, control catheters averaged greater than 10(2) CFU of S. aureus removed compared with less than 10(1.5) CFU for the dicloxacillin-coated catheters (P less than 0.05). No difference was found between coated and control catheters when S. aureus was inoculated 48 h after catheter insertion, but S. aureus titers averaged less than 10(2) CFU for all experimental groups. Our data suggest that in mice, regional prophylaxis of S. aureus subcutaneous space infection is feasible with catheters coated with dicloxacillin and that the presence of antibiotic is only necessary for the first 24 to 48 h.
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Author D D Solomon
R J Sherertz
D M Forman
AuthorAffiliation Department of Medicine, University of Florida School of Medicine, Gainesville 32610
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Issue 8
Keywords Rodentia
Catheter
Embedding
Infection
Prevention
In vivo
Vertebrata
Antibiotic
Chemotherapy
Experimental disease
Mammalia
Treatment
Mouse
Animal
Bacteriosis
Bacteria
Micrococcales
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Micrococcaceae
Staphylococcus aureus
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In a mouse model, dicloxacillin-coated polyurethane catheters or control (uncoated) catheters were placed subcutaneously and then Staphylococcus aureus was...
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SubjectTerms Animals
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Catheterization
Dicloxacillin
Dicloxacillin - analysis
Dicloxacillin - therapeutic use
Half-Life
Medical sciences
Mice
Mice, Inbred ICR
Pharmacology. Drug treatments
Research Article
Skin Diseases, Infectious
Skin Diseases, Infectious - prevention & control
Staphylococcal Infections
Staphylococcal Infections - microbiology
Staphylococcal Infections - prevention & control
Time Factors
Title Efficacy of dicloxacillin-coated polyurethane catheters in preventing subcutaneous Staphylococcus aureus infection in mice
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https://www.ncbi.nlm.nih.gov/pubmed/2802545
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Volume 33
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