One-Step Continuous Flow Synthesis of Highly Substituted Pyrrole-3-carboxylic Acid Derivatives via in Situ Hydrolysis of tert-Butyl Esters
The first one-step, continuous flow synthesis of pyrrole-3-carboxylic acids directly from tert-butyl acetoacetates, amines, and 2-bromoketones is reported. The HBr generated as a byproduct in the Hantzsch reaction was utilized in the flow method to hydrolyze the t-butyl esters in situ to provide the...
Saved in:
Published in | Organic letters Vol. 12; no. 22; pp. 5182 - 5185 |
---|---|
Main Authors | , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
19.11.2010
Amer Chemical Soc |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Be the first to leave a comment!