Digestion of Plant Dietary miRNAs Starts in the Mouth under the Protection of Coingested Food Components and Plant-Derived Exosome-like Nanoparticles

• Published in: Journal of agricultural and food chemistry Vol. 70; no. 14; pp. 4316 - 4327
• Main Authors: Qin, Xinshu, Wang, Xingyu, Xu, Ke, Zhang, Yi, Ren, Xiaoyu, Qi, Bangran, Liang, Qian, Yang, Xingbin, Li, Lin, Li, Shiqi
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 13.04.2022
• Subjects: Analytical chemistry; Animals; Bioactive Constituents, Metabolites, and Functions; Chemical Sciences; Digestion; digestive tract; food chemistry; Humans; ingestion; Mammals - metabolism; Material chemistry; microRNA; MicroRNAs - genetics; MicroRNAs - metabolism; Mouth - metabolism; Nanoparticles; or physical chemistry; Plants - metabolism; Polymers; ribonucleases; RNA, Plant - metabolism; saliva; Theoretical and; plant xenomiRNAs; microcapsules; cross-kingdom regulation; oral digestion; food components; exosome-like nanoparticles

The regulatory functions of plant miRNAs on mammalian bodies are controversial, mainly because stability of the miRNAs in the digestive tract, as the prerequisite for their cross-kingdom effects, has somehow been overlooked. Hence, as the first stage of food ingestion, stability of plant miRNAs in h...