Surface Charge and Cellular Processing of Covalently Functionalized Multiwall Carbon Nanotubes Determine Pulmonary Toxicity

• Published in: ACS nano Vol. 7; no. 3; pp. 2352 - 2368
• Main Authors: Li, Ruibin, Wang, Xiang, Ji, Zhaoxia, Sun, Bingbing, Zhang, Haiyuan, Chang, Chong Hyun, Lin, Sijie, Meng, Huan, Liao, Yu-Pei, Wang, Meiying, Li, Zongxi, Hwang, Angela A, Song, Tze-Bin, Xu, Run, Yang, Yang, Zink, Jeffrey I, Nel, André E, Xia, Tian
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 26.03.2013
• Subjects: Animals; Biocompatibility; Biological Transport, Active; Cationic; Cell Line; Cellular; Cytokines - biosynthesis; Fibrosis; Humans; Inflammasomes - drug effects; Inflammasomes - metabolism; Lung - drug effects; Lung - metabolism; Lung - pathology; Lung Injury - chemically induced; Male; Mathematical models; Mice; Mice, Inbred C57BL; Multi wall carbon nanotubes; Nanotechnology; Nanotubes, Carbon - chemistry; Nanotubes, Carbon - toxicity; Nanotubes, Carbon - ultrastructure; Polyethylene glycol; Pulmonary Fibrosis - chemically induced; Pulmonary Fibrosis - pathology; Spectroscopy, Fourier Transform Infrared; Static Electricity; Surface charge; Surface Properties; Tubes; multiwall carbon nanotube; charge; NLRP3 inflammasome; lung fibrosis; surface functionalization

Functionalized carbon nanotubes (f-CNTs) are being produced in increased volume because of the ease of dispersion and maintenance of the pristine material physicochemical properties when used in composite materials as well as for other commercial applications. However, the potential adverse effects...