Use of Metal Oxide Nanoparticle Band Gap To Develop a Predictive Paradigm for Oxidative Stress and Acute Pulmonary Inflammation

• Published in: ACS nano Vol. 6; no. 5; pp. 4349 - 4368
• Main Authors: Zhang, Haiyuan, Ji, Zhaoxia, Xia, Tian, Meng, Huan, Low-Kam, Cecile, Liu, Rong, Pokhrel, Suman, Lin, Sijie, Wang, Xiang, Liao, Yu-Pei, Wang, Meiying, Li, Linjiang, Rallo, Robert, Damoiseaux, Robert, Telesca, Donatello, Mädler, Lutz, Cohen, Yoram, Zink, Jeffrey I, Nel, Andre E
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 22.05.2012
• Subjects: Acute Disease; Animals; Biocompatibility; Cellular; Conduction band; COPPER OXIDE; Energy levels; MATHEMATICAL ANALYSIS; Mathematical models; Metal Nanoparticles - chemistry; Mice; Mice, Inbred C57BL; MOX; Nanoparticles; Oxidative Stress; OXIDES; PARTICLES; Pneumonia - metabolism; SEMICONDUCTORS; STRESS; Stresses; band gap energy; metal oxide nanoparticles; surface dissolution; oxidative stress; in vitro and in vivo toxicity

We demonstrate for 24 metal oxide (MOx) nanoparticles that it is possible to use conduction band energy levels to delineate their toxicological potential at cellular and whole animal levels. Among the materials, the overlap of conduction band energy (E c) levels with the cellular redox potential (−4...