Environmental Photochemistry of Altrenogest: Photoisomerization to a Bioactive Product with Increased Environmental Persistence via Reversible Photohydration

• Published in: Environmental science & technology Vol. 50; no. 14; pp. 7480 - 7488
• Main Authors: Wammer, Kristine H, Anderson, Kyler C, Erickson, Paul R, Kliegman, Sarah, Moffatt, Marianna E, Berg, Stephanie M, Heitzman, Jackie A, Pflug, Nicholas C, McNeill, Kristopher, Martinovic-Weigelt, Dalma, Abagyan, Ruben, Cwiertny, David M, Kolodziej, Edward P
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 19.07.2016
• Subjects: androgen receptors; Bioassays; Biological activity; Cells; cycloaddition reactions; Environment; environmental fate; genes; Half-Life; Hydration; isomers; oxygen; Photochemistry; Photolysis; risk; screening; spectroscopy; Temperature; transcriptional activation; veterinary drugs

Despite its wide use as a veterinary pharmaceutical, environmental fate data is lacking for altrenogest, a potent synthetic progestin. Here, it is reported that direct photolysis of altrenogest under environmentally relevant conditions was extremely efficient and rapid (half-life ∼25 s). Photolysis...