Pharmaceutical Applications of Cellulose Ethers and Cellulose Ether Esters

Cellulose ethers have proven to be highly useful natural-based polymers, finding application in areas including food, personal care products, oil field chemicals, construction, paper, adhesives, and textiles. They have particular value in pharmaceutical applications due to characteristics including...

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Published inBiomacromolecules Vol. 19; no. 7; pp. 2351 - 2376
Main Authors Arca, Hale Cigdem, Mosquera-Giraldo, Laura I, Bi, Vivian, Xu, Daiqiang, Taylor, Lynne S, Edgar, Kevin J
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 09.07.2018
Subjects
adhesives
butyrates
carboxymethylcellulose
Cellulose - analogs & derivatives
cellulose acetate
crystal structure
Drug Delivery Systems - methods
enterocytes
Esters - chemistry
ethers
fabrics
Food and Drug Administration
glass transition temperature
hydrogen bonding
oil fields
personal care products
photochemistry
polymers
solubility
succinic acid
toxicity
Online AccessGet full text
ISSN1525-7797
1526-4602
1526-4602
DOI10.1021/acs.biomac.8b00517

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Abstract Cellulose ethers have proven to be highly useful natural-based polymers, finding application in areas including food, personal care products, oil field chemicals, construction, paper, adhesives, and textiles. They have particular value in pharmaceutical applications due to characteristics including high glass transition temperatures, high chemical and photochemical stability, solubility, limited crystallinity, hydrogen bonding capability, and low toxicity. With regard to toxicity, cellulose ethers have essentially no ability to permeate through gastrointestinal enterocytes and many are already in formulations approved by the U.S. Food and Drug Administration. We review pharmaceutical applications of these valuable polymers from a structure–property–function perspective, discussing each important commercial cellulose ether class; carboxymethyl cellulose, methyl cellulose, hydroxypropylcellulose, hydroxypropyl methyl cellulose, and ethyl cellulose, and cellulose ether esters including hydroxypropyl methyl cellulose acetate succinate and carboxymethyl cellulose acetate butyrate. We also summarize their syntheses, basic material properties, and key pharmaceutical applications.
AbstractList Cellulose ethers have proven to be highly useful natural-based polymers, finding application in areas including food, personal care products, oil field chemicals, construction, paper, adhesives, and textiles. They have particular value in pharmaceutical applications due to characteristics including high glass transition temperatures, high chemical and photochemical stability, solubility, limited crystallinity, hydrogen bonding capability, and low toxicity. With regard to toxicity, cellulose ethers have essentially no ability to permeate through gastrointestinal enterocytes and many are already in formulations approved by the U.S. Food and Drug Administration. We review pharmaceutical applications of these valuable polymers from a structure–property–function perspective, discussing each important commercial cellulose ether class; carboxymethyl cellulose, methyl cellulose, hydroxypropylcellulose, hydroxypropyl methyl cellulose, and ethyl cellulose, and cellulose ether esters including hydroxypropyl methyl cellulose acetate succinate and carboxymethyl cellulose acetate butyrate. We also summarize their syntheses, basic material properties, and key pharmaceutical applications.
Cellulose ethers have proven to be highly useful natural-based polymers, finding application in areas including food, personal care products, oil field chemicals, construction, paper, adhesives, and textiles. They have particular value in pharmaceutical applications due to characteristics including high glass transition temperatures, high chemical and photochemical stability, solubility, limited crystallinity, hydrogen bonding capability, and low toxicity. With regard to toxicity, cellulose ethers have essentially no ability to permeate through gastrointestinal enterocytes and many are already in formulations approved by the U.S. Food and Drug Administration. We review pharmaceutical applications of these valuable polymers from a structure-property-function perspective, discussing each important commercial cellulose ether class; carboxymethyl cellulose, methyl cellulose, hydroxypropylcellulose, hydroxypropyl methyl cellulose, and ethyl cellulose, and cellulose ether esters including hydroxypropyl methyl cellulose acetate succinate and carboxymethyl cellulose acetate butyrate. We also summarize their syntheses, basic material properties, and key pharmaceutical applications.Cellulose ethers have proven to be highly useful natural-based polymers, finding application in areas including food, personal care products, oil field chemicals, construction, paper, adhesives, and textiles. They have particular value in pharmaceutical applications due to characteristics including high glass transition temperatures, high chemical and photochemical stability, solubility, limited crystallinity, hydrogen bonding capability, and low toxicity. With regard to toxicity, cellulose ethers have essentially no ability to permeate through gastrointestinal enterocytes and many are already in formulations approved by the U.S. Food and Drug Administration. We review pharmaceutical applications of these valuable polymers from a structure-property-function perspective, discussing each important commercial cellulose ether class; carboxymethyl cellulose, methyl cellulose, hydroxypropylcellulose, hydroxypropyl methyl cellulose, and ethyl cellulose, and cellulose ether esters including hydroxypropyl methyl cellulose acetate succinate and carboxymethyl cellulose acetate butyrate. We also summarize their syntheses, basic material properties, and key pharmaceutical applications.
Author Taylor, Lynne S
Xu, Daiqiang
Arca, Hale Cigdem
Bi, Vivian
Mosquera-Giraldo, Laura I
Edgar, Kevin J
AuthorAffiliation Department of Sustainable Biomaterials
Department of Industrial and Physical Pharmacy
Purdue University
Virginia Tech
Macromolecules and Interfaces Institute
AuthorAffiliation_xml – name: Virginia Tech
– name: Department of Industrial and Physical Pharmacy
– name: Purdue University
– name: Department of Sustainable Biomaterials
– name: Macromolecules and Interfaces Institute
Author_xml – sequence: 1
  givenname: Hale Cigdem
  surname: Arca
  fullname: Arca, Hale Cigdem
– sequence: 2
  givenname: Laura I
  surname: Mosquera-Giraldo
  fullname: Mosquera-Giraldo, Laura I
  organization: Purdue University
– sequence: 3
  givenname: Vivian
  surname: Bi
  fullname: Bi, Vivian
– sequence: 4
  givenname: Daiqiang
  surname: Xu
  fullname: Xu, Daiqiang
– sequence: 5
  givenname: Lynne S
  orcidid: 0000-0002-4568-6021
  surname: Taylor
  fullname: Taylor, Lynne S
  organization: Purdue University
– sequence: 6
  givenname: Kevin J
  orcidid: 0000-0002-9459-9477
  surname: Edgar
  fullname: Edgar, Kevin J
  email: kjedgar@vt.edu
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29869877$$D View this record in MEDLINE/PubMed
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Snippet Cellulose ethers have proven to be highly useful natural-based polymers, finding application in areas including food, personal care products, oil field...
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SubjectTerms adhesives
butyrates
carboxymethylcellulose
Cellulose - analogs & derivatives
cellulose acetate
crystal structure
Drug Delivery Systems - methods
enterocytes
Esters - chemistry
ethers
fabrics
Food and Drug Administration
glass transition temperature
hydrogen bonding
oil fields
personal care products
photochemistry
polymers
solubility
succinic acid
toxicity
Title Pharmaceutical Applications of Cellulose Ethers and Cellulose Ether Esters
URI http://dx.doi.org/10.1021/acs.biomac.8b00517
https://www.ncbi.nlm.nih.gov/pubmed/29869877
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Volume 19
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